| Prostate dysfunction is the most common condition among aged men, which causes adverse complications and may result in serious diseases. Artemisia has been studied since time immemorial in several studies all showing its ability in preventing and treating different diseases. However, so far there have been no studies focusing on the possible role of Artemisia in the protection of prostate histoarchitecture toxicity. Therefore, this study aimed to investigate the protective role of Artemisia in the amelioration of histological and hormonal depression affected by sodium fluoride (NaF). A total of 28 male adult Wistar rats were equally divided into four groups (n=7). Animals in the control group received normal saline. The second group received NaF by oral gavage at a dose of 12 mg/kg body weight (B.W.) three times a week. The third group received concurrent treatment with NaF at a dose of 12 mg/kg B.W. three times a week, as well as extraction of Artemisia absinthium at a dose of 100 mg/kg B.W. The fourth group was treated only with extraction of Artemisia absinthium at a dose of 100 mg/k B.W. After 60 days, B.W. and the absolute weight of the prostate were measured. Blood samples and tissues were collected for measuring testosterone, follicle-stimulating hormone, as well as luteinizing hormone concentration, conducting paraffin-embedded sections with hematoxylin, and eosin routine staining. The findings revealed that Artemisia supplement significantly increased body and absolute weight of prostate gland in the group treated by NaF. In addition, mitigating the histological changes throughout the restoration of all prostate components appeared nearly as normal structural tissue. Moreover, the height of glandular epithelium decreased, follicular lumen enlarged, dark secretion materials with homogeneity disappeared of invagination intraluminal, and normal stroma appeared in regular shape. All in all, the results of this study pointed out that Artemisia had a protective effect against NaF-influenced prostate toxicity via stabilizing male hormones, re-composing histoarchitecture, and returning abnormal biomorphic parameters to a nearly normal state. |
- Barkin J, Roehrborn CG, Siami P, Haillot O, Morrill B, Black L, et al. Effect of dutasteride, tamsulosin and the combination on patient‐reported quality of life and treatment satisfaction in men with moderate‐to‐severe benign prostatic hyperplasia: 2‐year data from the CombAT trial. BJU Int. 2009;103(7):919-26.
- Zhong X, Lin J, Zhou J, Xu W, Hong Z. Anti-proliferative effects of qianliening capsules on prostatic hyperplasia in vitro and in vivo. Mol Med Rep. 2015;12(2):1699-708.
- Krieger J, Ross S, Riley D. Chronic prostatitis: epidemiology and role of infection. Urology. 2002;60(6):8-12.
- Nickel JC, Shoskes DA, Wagenlehner FM. Management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): the studies, the evidence, and the impact. World J Urol. 2013;31(4):747-53.
- Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, et al. Comprehensive overview of prostatitis. Biomed Pharmacother. 2017;94:1064-76.
- Akdere H, Oztekin I, Arda E, Aktoz T, Turan FN, Burgazli KM. Analgesic effects of oligonol, acupuncture and quantum light therapy on chronic nonbacterial prostatitis. Iran Red Crescent Med J. 2015;17(4).
- Said MM, Bosland MC. The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate. Naunyn Schmiedebergs Arch Pharmacol. 2017;390(2):197-205.
- William FP, Russa DA. Prunus africanus Herbal Extracts Reverse and Ameliorate the Histological and Histomorphometric Changes in Testosterone-induced Benign Prostate Hyperplasia Rat Models. Tanz J Sci. 2021;47(3):1184-94.
- Msaada K, Salem N, Bachrouch O, Bousselmi S, Tammar S, Alfaify A, et al. Chemical composition and antioxidant and antimicrobial activities of wormwood (Artemisia absinthium L.) essential oils and phenolics. J Chem. 2015;2015.
- Saleh HS, Ali HN. Tocotrienol Mitigating Adverse Effect of Doxorubicin on Pancreas Tissue in Male Rats. J Adv Biomed Pathobiol Res. 2015;5(2):23-31.
- Saleh HS, Al-Kayat ES. Modulation Male Fertility in Diabetic Rats by Allicin Administration. J Edu Pure Sci. 2017;7(1).
- Li S, Zhou S, Yang W, Meng D. Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress. J Ethnopharmacol. 2018;214:207-17.
- Ahuja A, Yi Y-S, Kim M-Y, Cho JY. Ethnopharmacological properties of Artemisia asiatica: A comprehensive review. J Ethnopharmacol. 2018;220:117-28.
- Chinoy N, Sorathia H, Jhala D. Fluoride+ aluminium induced toxicity in mice testis with giant cells and its reversal by vitamin C. Fluoride. 2005;38(2):109-14.
- Khriachtchev L, Pettersson M, Runeberg N, Lundell J, Räsänen M. A stable argon compound. Nature. 2000;406(6798):874-6.
- Sebert J, Richard P, Mennecier I, Bisset J, Loeb G. Monofluorophosphate increases lumbar bone density in osteopenic patients: a double-masked randomized study. Osteoporos Int. 1995;5(2):108-14.
- Peehl DM, Sellers RG. Induction of smooth muscle cell phenotype in cultured human prostatic stromal cells. Exp Cell Res. 1997;232(2):208-15.
- El-Din WAN, Fattah IOA. The potential curative and preventive effects of garlic on testosterone-induced benign prostatic hyperplasia in orchiectomized rats. Rom J Morphol Embryol. 2019;60(1):145-58.
- Shin IS, Lee MY, Ha HK, Seo CS, Shin H-K. Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats. BMC Complement Altern Med. 2012;12(1):1-7.
- Gacci M, Vignozzi L, Sebastianelli A, Salvi M, Giannessi C, De Nunzio C, et al. Metabolic syndrome and lower urinary tract symptoms: the role of inflammation. Prostate Cancer Prostatic Dis. 2013;16(1):101-6.
- Hao P, Ma X, Cheng X, Ba Y, Zhu J, Cui L. Effect of fluoride on human hypothalamus-hypophysis-testis axis hormones. Wei Sheng Yan Jiu. 2010;39(1):53-5.
- Agrawal M, Nahata A, Dixit VK. Protective effects of Echinops echinatus on testosterone-induced prostatic hyperplasia in rats. Eur J Integr Med. 2012;4(2):e177-e85.
- Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q 10: recent developments. Mol Biotechnol. 2007;37(1):31-7.
- Popoola B, Ashefor O, Akanni O, Adaramoye O. Biochemical, hormonal and histological changes in prostate of Wistar rats following long term streptozotocin-induced diabetes mellitus. Niger J Physiol Sci. 2017;32(1):75-84.
|
