اخبار و اعلانات

 آمار

تعداد نشریات287
تعداد نشریات سازمان85
تعداد شماره‌ها3,159
تعداد مقالات35,108
تعداد مشاهده مقاله50,528,734
تعداد دریافت فایل اصل مقاله90,477,651
Abdulazeem, L, Tariq, A, Jasim, Saade. (1401). An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing. سامانه مدیریت نشریات علمی, 77(2), 747-751. doi: 10.22092/ari.2022.356981.1954
L Abdulazeem; A Tariq; Saade A. Jasim. "An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing". سامانه مدیریت نشریات علمی, 77, 2, 1401, 747-751. doi: 10.22092/ari.2022.356981.1954
Abdulazeem, L, Tariq, A, Jasim, Saade. (1401). 'An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing', سامانه مدیریت نشریات علمی, 77(2), pp. 747-751. doi: 10.22092/ari.2022.356981.1954
Abdulazeem, L, Tariq, A, Jasim, Saade. An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing. سامانه مدیریت نشریات علمی, 1401; 77(2): 747-751. doi: 10.22092/ari.2022.356981.1954

An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing

Archives of Razi Institute
مقاله 31، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 747-751    اصل مقاله (363.91 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.356981.1954
نویسندگان
L Abdulazeem1؛ A Tariq2؛ Saade A. Jasim* 3
1DNA Research Center, University of Babylon, Babylon, Iraq
2Biology Department, College of Science, University of Babylon, Babylon, Iraq
3Medical Laboratory Techniques Department, Al-maarif University College, Al-anbar, Iraq
چکیده
Burn damage is a complicated trauma that causes local and general tissue edema as a result of cell breakage and capillary leak syndrome. Angiogenesis plays a key part in the mechanisms that are initiated by tissue damage (e.g., burns) since it works directly and precisely on endothelial cells. The primary mediators of angiogenesis are vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2). This study aimed to figure out what functions VEGF and its receptors play in wound healing after burn, and the systemic release of VEGF in people following severe burn damage. This study included 23 burnt adult serum and 20 healthy controls. The enzyme-linked immunosorbent test was used to assess circulating VEGF serum levels and its receptors (VEGFR-1 and VEGFR-2). VEGF serum levels were considerably higher in this study, compared to VEGF levels in healthy controls. The levels of VEGFR-1 and VEGFR-2 have significantly risen; moreover, VEGF and its receptors have a significant impact on edema-related problems in severely burned individuals. Burn is a frequent disease that damages the skin and induces the production of mediators that cause neovasculature in the majority of patients. VEGF, which causes vasculogenesis and angiogenesis, is one of the most important factors in the skin.
کلیدواژه‌ها
Angiogenesis؛ Burns؛ VEGF؛ VEGF receptors (VEGFR-1 and VEGFR-2)
سایر فایل های مرتبط با مقاله
مراجع
  1. Abdulazeem L, Al-Dahmoshi HO, Ali JA. Microbial Index and TNF-α, IL-4, CCL17 Level Among Burn Wound Infections in Hilla City, Iraq. Biomed Pharmacol J. 2016;9(3):1095-100.
  2. Jiang Y, Huang S, Fu X, Liu H, Ran X, Lu S, et al. Epidemiology of chronic cutaneous wounds in China. Wound Repair Regen. 2011;19(2):181-8.
  3. Letizia M, Uebelhor J, Paddack E. Providing palliative care to seriously ill patients with nonhealing wounds. J Wound Ostomy Continence Nurs. 2010;37(3):277-82.
  4. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18(1):4-25.
  5. Ruan Q, Zhao C, Ye Z, Ruan J, Xie Q, Xie W. Effect and possible mechanism of monocyte-derived VEGF on monocyte–endothelial cellular adhesion after electrical burns. Burns. 2015;41(4):825-32.
  6. Costa C, Incio J, Soares R. Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis. 2007;10(3):149-66.
  7. Xia YP, Li B, Hylton D, Detmar M, Yancopoulos GD, Rudge JS. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood. 2003;102(1):161-8.
  8. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-76.
  9. Elias PM, Arbiser J, Brown BE, Rossiter H, Man MQ, Cerimele F, et al. Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. Am J Pathol. 2008;173(3):689-99.
  10. Kajdaniuk D, Marek B, Borgiel-Marek H, Kos-Kudła B. Vascular endothelial growth factor (VEGF)—part 1: in physiology and pathophysiology. Endokrynol Pol. 2011;62(5):444-55.
  11. Nissen NN, Polverini P, Koch AE, Volin MV, Gamelli RL, DiPietro LA. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol. 1998;152(6):1445.
  12. Soyer T, Ayva S, Aliefendioglu D, Aktuna Z, Aslan MK, Senyucel MF, et al. Effect of phototherapy on growth factor levels in neonatal rat skin. J Pediatr Surg. 2011;46(11):2128-31.
  13. Ferrara N. VEGF: an update on biological and therapeutic aspects. Curr Opin Biotechnol. 2000;11(6):617-24.
  14. Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci. 1995;108 ( Pt 6):2369-79.
  15. Wang W, Dentler WL, Borchardt RT. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly. Am J Physiol Heart Circ Physiol. 2001;280(1):H434-40.
  1. Larcher F, Murillas R, Bolontrade M, Conti CJ, Jorcano JL. VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene. 1998;17(3):303-11.
  2. Dvorak HF, Nagy JA, Feng D, Brown LF, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol. 1999;237:97-132.
  3. Ruan Q, Xie W, Wen F. Change in expression of vascular endothelial growth factor in serum and wound tissue of rats with electrical burns. Zhonghua Shao Shang Za Zhi. 2012;28(6):423-7.
  4. Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood. 1996;87(8):3336-43.
  5. Senger DR, Connolly DT, Van de Water L, Feder J, Dvorak HF. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 1990;50(6):1774-8.
  6. Berse B, Brown LF, Van de Water L, Dvorak HF, Senger DR. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell. 1992;3(2):211-20.
  7. Malavaud B, Tack I, Jonca F, Praddaude F, Moro F, Ader J-L, et al. Activation of Flk-1/KDR mediates angiogenesis but not hypotension. Cardiovasc Res. 1997;36(2):276-81.
آمار
تعداد مشاهده مقاله: 1,832
تعداد دریافت فایل اصل مقاله: 3,079


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب