| Obesity is one of the most important global health problems causing serious health risks and early death in human. It is also associated with disturbance of homeostasis of hormones and immunological biochemical factors inside the human body. This study aimed to evaluate the serum level of inhibin B and kisspeptin among Iraqi obese adult people and other biochemical parameters correlated with obesity. Inhibin B and levels of kisspeptin were evaluated in the samples of serum from 40 Iraqi obese adult patients and 30 healthy non-obese individuals. A significant decrease (P<0.0001) was observed in the kisspeptin level in both males and females, compared to the control group. Moreover, inhibin B decreased significantly in obese females only (P<0.001), while there was no differences between males and the control group in this regard. Finally, body mass index, serum glutamic pyruvic transaminase (SGPT), and leptin showed negative correlation with kisspeptin (0.01, 0.5, and 0.01), respectively. However, a positive association was observed with the level of Ca in the serum. On the other hand, inhibin B confirmed a positive correlation with SGPT. The present study revealed a significant increase in inhibin B and kisspeptin, with SGPT and Ca in the serum of obese patients, which could lead to complications and health problems among these patients. |
- Chambers TJ, Richard RA. The impact of obesity on male fertility. Hormones. 2015;14(4):563-8.
- Du Plessis SS, Cabler S, McAlister DA, Sabanegh E, Agarwal A. The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 2010;7(3):153-61.
- Bilezikjian LM, Blount AL, Donaldson CJ, Vale WW. Pituitary actions of ligands of the TGF-beta family: activins and inhibins. Reproduction. 2006;132(2):207-15.
- Hayes FJ, Hall JE, Boeplle PA, Crowley WFJ. Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin. J Clin Endocrinol Metab. 1998;83: 1835-41.
- Reis FMD, Rezende CP. Clinical usefulness of inhibin assays in Gynecology and Obstetrics. J Revista Brasileira de Ginecologia e Obstetrícia. 2009;31:621-5.
- Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, et al. Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev. 2014;35(5):747-94.
- Laniyan D, Charles-Davies M, Fasanmade A, Olaniyi J, Oyewole O, Owolabi M, et al. Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components. J Sci Res Rep. 2016;10(5):1-2.
- Hestiantoro A, Astuti BPK, Muharam R, Pratama G, Witjaksono F, Wiweko B. Dysregulation of Kisspeptin and Leptin, as Anorexigenic Agents, Plays Role in the Development of Obesity in Postmenopausal Women. Int J Endocrinol. 2019;2019:1347208.
- Wolfe A, Hussain MA. The Emerging Role(s) for Kisspeptin in Metabolism in Mammals. Front Endocrinol. 2018;9:184.
- De Bond JA, Smith JT. Kisspeptin and energy balance in reproduction. Reproduction. 2014;147(3):R53-63.
- Turki S, Asmehan A, al-naqeeb A, Mohammed Z, Hameed W. Evaluation of Serum Leptin, Interlukein-6 and some Biochemical Parameters in Iraq obese Adult Patients. Medico-Legal Update. 2021;20:996-1002.
- Quennell JH, Howell CS, Roa J, Augustine RA, Grattan DR, Anderson GM. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology. 2011;152(4):1541-50.
- Rance NE. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides. 2009;30(1):111-22.
- Sharief M, Alharoon D, Mohammed H. Inhibin B as a Marker for Detection of Ovarian Activity in Premature Ovarian Failure. J Women's Health. 2018;07.
- Hassan H, Ghazi S. Study of a hormonal assay in PCOS patients with type 2 DM and their correlation with inhibin B. Med-Leg Update.2020; 20(3): 575–580
- Cortet-Rudelli C, Pigny P, Decanter C, Leroy M, Maunoury-Lefebvre C, Thomas-Desrousseaux P, et al. Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome. Fertil Steril. 2002;77(2):281-7.
- Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005;31(1):17-26.
- Harter CJL, Kavanagh GS, Smith JT. The role of kisspeptin neurons in reproduction and metabolism. J Endocrinol. 2018;238(3): 173-83.
- Crujeiras AB, Carreira MC, Cabia B, Andrade S, Amil M, Casanueva FF. Leptin resistance in obesity: An epigenetic landscape. Life Sci. 2015;140:57-63.
- Babwah AV, Pampillo M, Min L, Kaiser UB, Bhattacharya M. Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+. Endocrinology. 2012;153(12):5875-87.
- Dalfardi O, Jahandideh D, Ranjbar Omrani GH. The Correlation of Serum Calcium Level and Obesity; Is There Any Explanation? Galen Med J. 2013;2(1):26-31.
- Fabian UA, Charles-Davies MA, Fasanmade AA, Olaniyi JA, Oyewole OE, Owolabi MO, et al. Male Sexual Dysfunction, Leptin, Pituitary and Gonadal Hormones in Nigerian Males with Metabolic Syndrome and Type 2 Diabetes Mellitus.J Reprod Infertil. 2016;17(1):17-25.
- Okoli S, Charles-Davies M, Onifade A, Adekola S. Hypogonadism in Males Exposed to Mixed Chemicals in a Mechanic Village in Bodija, Ibadan. J Sci Res Rep. 2015;8(7):1-9.
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