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Islam, F, Akter, A, Mimi, A. A, Urmee, H, Islam, Md. R, Rahaman, Md. S, Mamun, A. A, Rahman, Md. M, Dhama, K, Emran, T. B. (1401). Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model. سامانه مدیریت نشریات علمی, 77(2), 881-890. doi: 10.22092/ari.2021.356880.1937
F Islam; A Akter; A. A Mimi; H Urmee; Md. R Islam; Md. S Rahaman; A. A Mamun; Md. M Rahman; K Dhama; T. B Emran. "Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model". سامانه مدیریت نشریات علمی, 77, 2, 1401, 881-890. doi: 10.22092/ari.2021.356880.1937
Islam, F, Akter, A, Mimi, A. A, Urmee, H, Islam, Md. R, Rahaman, Md. S, Mamun, A. A, Rahman, Md. M, Dhama, K, Emran, T. B. (1401). 'Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model', سامانه مدیریت نشریات علمی, 77(2), pp. 881-890. doi: 10.22092/ari.2021.356880.1937
Islam, F, Akter, A, Mimi, A. A, Urmee, H, Islam, Md. R, Rahaman, Md. S, Mamun, A. A, Rahman, Md. M, Dhama, K, Emran, T. B. Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model. سامانه مدیریت نشریات علمی, 1401; 77(2): 881-890. doi: 10.22092/ari.2021.356880.1937

Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model

Archives of Razi Institute
مقاله 46، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 881-890    اصل مقاله (417.94 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356880.1937
نویسندگان
F Islam1؛ A Akter1؛ A. A Mimi1؛ H Urmee2؛ Md. R Islam1؛ Md. S Rahaman1؛ A. A Mamun3؛ Md. M Rahman1؛ K Dhama4؛ T. B Emran* 5
1Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh
2Department of Pharmaceutical Science, North South University, Dhaka, Bangladesh
3Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
4Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
5Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh
چکیده
The current study aimed to investigate the neuropharmacological properties of ethanol, acetone, and ethyl acetate leaf extracts of Chassalia curviflora (C. curviflora) in mouse models. The neuropharmacological properties of this plant were studied on Swiss albino mice at dosages of 50, 100, and 200 mg/kg body weight in thiopental sodium-induced sleeping time test, and at dosages of 100 and 200 mg/kg body weight in other tests. The extracts caused a marked reduction in the initiation and sleep length (P<0.05) in studies on thiopental sodium-induced sleeping time at dosages of 100 and 200 mg/kg and a significant decrease (P<0.05) was found in terms of unconstrained locomotor and explorative activities in both hole crossing and open field tests at dosages of 100 and 200 mg/kg. Furthermore, the extracts increased sleeping time with a dosage-dependent onset of action. The hole-board test extracts also reduced the number of head dips at dosages of 100 and 200 mg/kg (P<0.05). It was found in this study that C. curviflora had the best neuropharmacological properties at a dosage of 200 ml/kg. Our findings also showed that all of the extracts from C. curviflora were experimentally active in an in vivo model. The study results suggested that the leaves had strong anti-depressant and hypnotic CNS properties that might be exploited for neuropharmacological adjuvant therapy in conventional medicine. However, pharmacological studies are warranted to explore the active substances and the mode of action.
کلیدواژه‌ها
Chassalia curviflora؛ Gamma-aminobutyric acid؛ Latent period؛ Locomotor behavior؛ Neuropharmacological potential
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