1Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
چکیده
Pycnocycla bashgardiana is used in Iranian traditional medicine for the relief and treatment of pain and inflammatory disorder. This study investigates the anti-inflammatory and anti-nociceptive activities of P.bashgardiana essential oil (PBEO).The anti-inflammatory effect of PBEO (50, 100, and 200 mg/kg, i.p.) were determined using carrageenan test in rat. The analgesic activity of PBEO (20, 50, 100, and 200 mg/kg, i.p.) was studied by formalin test in mice. PBEO (50, 100, and 200 mg/kg) significantly (p<0.05) inhibited the carrageenan-induced paw edema which was observed at the 3rd hour of the experiment by 43, 64 and 58%, respectively. PBEO showed significant anti-nociceptive effects in the first phase (200 mg/kg, 40% pain inhibition) and the second phase (100 mg/kg, 37% pain inhibition) of formalin test. According to the GC-Mass spectrometry findings, myristicin (21.1%), cis-isomyristicin (17.2%), E-β-ocimene (11.1%), and Z-β-ocimene (6.2%) were characterized as the main components. The results suggest that PBEO could be a potential candidate as an anti-inflammatory and anti-nociceptive agent in the management of inflammation-based disorders. These effects might be partially due to possible inhibition of or interference with the production of some inflammatory mediators.
Mozaffarian V. A dictionary of Iranian plant names. Farhang Mosavar Publ., Tehran, Iran. 2006.
Fullerton J.N. and Gilroy D.W. Resolution of inflammation: a new therapeutic frontier. Nature reviews Drug discovery. 2016;15:551-567.
Rainsford K., Profile and mechanisms of gastrointestinal and other side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). The American J Medicine. 1999;107:27-35.
Sadraei H., G. Asghari, and A. Hekmatti. Antispasmodic effect of three fractions of hydroalcoholic extract of Pycnocycla spinosa. J Ethnopharmacology. 2003;86:187-190.
Sadraei H., G. Asghari, and M. Alipour. Anti-spasmodic assessment of hydroalcoholic extract and essential oil of aerial part of Pycnocycla caespitosa & Hausskn on rat ileum contractions. Research in Pharmaceutical Sci. 2016;11:33-42.
Sadraei H., et al. Antispasmodic and antidiarrhoeal activities of 6-(4-hydroxy-3-methoxyphenyl)-hexanonic acid from Pycnocycla spinosa exBoiss. Research in Pharmaceutical Sci. 2014;9:279-286.
Alizadeh A. and Abdollahzadeh H. Essential oil constituents and antimicrobial activity of Pycnocycla bashagardiana from Iran. Natural Product Research. 2017;31:2081-2084.
Sadraei H., Ghannadi A., and Malekshahi K. Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. Fitoterapia. 2003;74:445-452.
Mahboubi M., Taghizadeh M., and Kazempour N. Antimicrobial and antioxidant activities of Pycnocycla spinosa Jundishapur J Natural Pharmaceutical Products. 2014;9:e13859..
Mahboubi M., Mahdizadeh E., and Tabar R.H. The chemical composition, antimicrobial, and antioxidant activities of Pycnocycla spinosa and Pycnocyla flabellifolia essential oils. Zeitschrift für Naturforschung C. 2016;71:403-408.
Sadraei H., et al. Evaluation of cardiovascular effect of Pycnocycla spinosa exBoiss. var. spinosa extract in anaesthetized rat. DARU J Pharmaceutical Sci. 2006;14:11-14.
Sadraei H., Asghari G., and Naddafi A. Relaxant effect of essential oil and hydro‐alcoholic extract of Pycnocycla spinosa exBoiss. on ileum contractions. Phytotherapy Research. 2003;17:645-649.
Jahandar F., et al. Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models. Iranian J Basic Medical Sci. 2018;21:188-193.
Adams R. Identification of essential oil components by GC/MS. Allured Publ. Corp., Carol Stream, IL. 1995.
Rangriz E., et al. Antinociceptive effect of the endemic species glaucium vitellinum boiss and buhse. Jundishapur J Natural Pharmaceutical Products. 2016;11.
Morris C.J. Carrageenan-induced paw edema in the rat and mouse, in Inflammation protocols. 2003;115-121.
Brunton L., B. Chabner, and B. Knollman. Goodman and Gilman’s the pharmacological basis of therapeutics, ed 12, New York, McGraw-Hill. 2010.
Lee J.Y., and W. Park. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules. 2011;16:7132-7142.
Serhan C.N., N. Chiang, and T.E. Van Dyke. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews Immunology. 2008;8:349-361.
Bomfim L.M., Menezes L.R., Rodrigues A.C.B., Dias R.B., Gurgel Rocha C.A., Soares M.B., Neto A.F., Nascimento M.P., Campos A.F., Silva L.C.E., Costa E.V. Antitumour activity of the microencapsulation of Annona vepretorum essential oil. Basic & Clinical Pharmacology & Toxicology. 2016; 118:208-213.
Cascone P., Iodice L., Maffei M.E., Bossi S., Arimura G.I., Guerrieri E. Tobacco overexpressing β-ocimene induces direct and indirect responses against aphids in receiver tomato plants, J Plant Physiology. 2015;173:28-32.
Sayyah M., Nadjafnia L., Kamalinejad M. Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil. J Ethnopharmacology. 2004;94:283-287.
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