اخبار و اعلانات

 آمار

تعداد نشریات287
تعداد نشریات سازمان85
تعداد شماره‌ها3,159
تعداد مقالات35,108
تعداد مشاهده مقاله50,526,952
تعداد دریافت فایل اصل مقاله90,476,644
Nasser, F. A, Younis, L. A, Abidreda, K. H, Alyasiri, I. (1400). Importance of Vitamin D3 in COVID-19 Patients. سامانه مدیریت نشریات علمی, 76(5), 1545-1549. doi: 10.22092/ari.2021.356070.1769
F. A Nasser; L. A Younis; K. H Abidreda; I Alyasiri. "Importance of Vitamin D3 in COVID-19 Patients". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1545-1549. doi: 10.22092/ari.2021.356070.1769
Nasser, F. A, Younis, L. A, Abidreda, K. H, Alyasiri, I. (1400). 'Importance of Vitamin D3 in COVID-19 Patients', سامانه مدیریت نشریات علمی, 76(5), pp. 1545-1549. doi: 10.22092/ari.2021.356070.1769
Nasser, F. A, Younis, L. A, Abidreda, K. H, Alyasiri, I. Importance of Vitamin D3 in COVID-19 Patients. سامانه مدیریت نشریات علمی, 1400; 76(5): 1545-1549. doi: 10.22092/ari.2021.356070.1769

Importance of Vitamin D3 in COVID-19 Patients

Archives of Razi Institute
مقاله 44، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1545-1549    اصل مقاله (398.03 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356070.1769
نویسندگان
F. A Nasser* ؛ L. A Younis؛ K. H Abidreda؛ I Alyasiri
College of Pharmacy, Jabir Ibn Hayyan Medical University, Najaf, Iraq
چکیده
Outbreaks of a respiratory ailment in Wuhan, China, known as the Corona virus Disease-2019 (COVID-19), began in late December 2019. Since then, several pieces of advice have been made to boost the immune system to fight more efficiently with this infection. Previously published studies showed that vitamin D3 (Vit D3) level was low in COVID-19 patients. One of the most important factors in COVID-19 severity would be the inflammatory response. It is well documented that the inflammatory cytokine storm increases the severity of COVID-19. Cytokine storm results from dysregulation of the innate immune system with an outpouring of proinflammatory cytokines and chemokines, leading to abnormal activation of the adaptive immune pathway. It has been approved that Vit D3 has immunomodulatory functions and plays an anti-inflammatory role, particularly in viral infections. Therefore, the current study was designed to investigate the possible role of Vit D3 deficiency in the COVID-19 patients' innate immunity. This study included 180 participants who were divided into group (A) consisted of 60 COVID-19 positive patients with normal level of Vit D3, group (B) consisted of 60 COVID-19 positive patients with Vit D3 deficiency, and group (C) consisted of 60 COVID-19 positive patients that had received Vit D3 therapy. The results showed that the rate of hospitalization in the group (B) (41.3%) was significantly increased, compared to group (A) (12.5%). In this regard, Vit D3 therapy led to a significant increase in the level of Vit D3, and the patients who received Vit D3 were recovered from hospital 5 days on average sooner than those in the group (B). Therefore, the consumption of Vit D3 as a daily supplement would be a reasonable suggestion for these days of the COVID-19 pandemic to increase the power of immunity of the body.
کلیدواژه‌ها
Coronavirus (COVID-19)؛ Health؛ Risks؛ Vitamin D3
سایر فایل های مرتبط با مقاله
مراجع
  1. Su S, Wong G, Shi W, Liu J, Lai AC, Zhou J, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24(6):490-502.
  2. De Wit E, Van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14(8):523-34.
  3. Channappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, et al. IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes. J Clin Investig. 2019;129(9):3625-39.
  4. Bikle DD. What is new in vitamin D: 2006–2007. Curr Opin Rheumatol. 2007;19(4):383-8.
  5. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25-dihydroxyvitamin D3. J Cyst Fibros. 2007;6(6):403-10.
  6. Moan J, Porojnicu AC, Dahlback A, Setlow RB. Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure. PNA S. 2008;105(2):668-73.
  7. Reichrath J. Vitamin D and the skin: an ancient friend, revisited. Experimental dermatology. 2007;16(7):618-25.
  8. Maghbooli Z, Sahraian MA, Ebrahimi M, Pazoki M, Kafan S, Tabriz HM, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PloS One. 2020;15(9):0239799.
  9. Merzon E, Tworowski D, Gorohovski A, Vinker S, Golan Cohen A, Green I, et al. Low plasma 25 (OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study. FEBS J. 2020;287(17):3693-702.
  1. Munshi R, Hussein MH, Toraih EA, Elshazli RM, Jardak C, Sultana N, et al. Vitamin D insufficiency as a potential culprit in critical COVID‐19 patients. J Med Virol. 2021;93(2):733-40.
  2. Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PloS One. 2020;15(9):0239252.
  3. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):2019722.
  4. Han JE, Jones JL, Tangpricha V, Brown MA, Hao L, Hebbar G, et al. High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial. J Clin Transl Endocrinol. 2016;4:59-65.
  5. Lei G-S, Zhang C, Cheng B-H, Lee C-H. Mechanisms of action of vitamin D as supplemental therapy for Pneumocystis pneumonia. Antimicrob Agents Chemother. 2017;61(10):e01226-17.
آمار
تعداد مشاهده مقاله: 1,880
تعداد دریافت فایل اصل مقاله: 3,135


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب