اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,081
تعداد مقالات34,377
تعداد مشاهده مقاله48,002,686
تعداد دریافت فایل اصل مقاله78,922,317
Gorelik, S. G, Kolesnikov, S. A, Zheludev, A. A, Parkhisenko, Y. A, Bulynin, V. V. (1400). Effect of Electroactive Water Solutions on Homeostasis and Healing Processes of Intestinal Anastomosis Combined with Simulated Anemia in Wistar Rats. سامانه مدیریت نشریات علمی, 76(4), 965-974. doi: 10.22092/ari.2021.356007.1763
S. G Gorelik; S. A Kolesnikov; A. A Zheludev; Y. A Parkhisenko; V. V Bulynin. "Effect of Electroactive Water Solutions on Homeostasis and Healing Processes of Intestinal Anastomosis Combined with Simulated Anemia in Wistar Rats". سامانه مدیریت نشریات علمی, 76, 4, 1400, 965-974. doi: 10.22092/ari.2021.356007.1763
Gorelik, S. G, Kolesnikov, S. A, Zheludev, A. A, Parkhisenko, Y. A, Bulynin, V. V. (1400). 'Effect of Electroactive Water Solutions on Homeostasis and Healing Processes of Intestinal Anastomosis Combined with Simulated Anemia in Wistar Rats', سامانه مدیریت نشریات علمی, 76(4), pp. 965-974. doi: 10.22092/ari.2021.356007.1763
Gorelik, S. G, Kolesnikov, S. A, Zheludev, A. A, Parkhisenko, Y. A, Bulynin, V. V. Effect of Electroactive Water Solutions on Homeostasis and Healing Processes of Intestinal Anastomosis Combined with Simulated Anemia in Wistar Rats. سامانه مدیریت نشریات علمی, 1400; 76(4): 965-974. doi: 10.22092/ari.2021.356007.1763

Effect of Electroactive Water Solutions on Homeostasis and Healing Processes of Intestinal Anastomosis Combined with Simulated Anemia in Wistar Rats

Archives of Razi Institute
مقاله 26، دوره 76، شماره 4، آذر و دی 2021، صفحه 965-974    اصل مقاله (637.12 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356007.1763
نویسندگان
S. G Gorelik* 1؛ S. A Kolesnikov1؛ A. A Zheludev2؛ Y. A Parkhisenko2؛ V. V Bulynin2
1Belgorod State University, 85, Pobedy St., Belgorod, 308015, Russia
2Voronezh State Medical University named after N.N. Burdenko, 10, Studencheskaya st., Voronezh, 394036, Russia
چکیده
Gastroduodenal bleeding is one of the most challenging issues in surgery nowadays. The crude mortality rate due to severe blood loss in gastrointestinal bleeding is very high. Therefore, the use of medications to prevent severe blood loss and protect cells from the harmful effects of hypoxia should be the focus of attention in these conditions. This experimental study was carried out to establish changes in blood parameters and humoral immunity in rats after intestinal anastomoses combined with acute blood loss after the application of catholyte and anolyte. The study included 45 male Wistar rats weighing 290-320 g that were divided equally (15 animals per group) into three groups of intact animals (group 1), animals exposed to the small bowel resection (1.5 cm) with the end-to-end anastomosis and simulated acute blood loss (group 2), and animals exposed to the small bowel resection with end-to-end anastomosis and simulated acute blood loss that were daily given catholyte in the postoperative period group (group 3). After the surgery, the rats were given a catholyte solution per os, and the operative wound was treated with an anolyte. The blood samples and the wall of the small intestine in the anastomotic zone were used as a biological substrate to study the effect of catholyte on changes in the body during the healing process. The experiment was conducted for 15 days, and the data were recorded in two intervals on the 5th and 15th days after starting the experiment. The analyzed materials evidenced that the use of catholyte and liquid with negative oxidoreduction potential (ORP) (minus 500-520 mV) resulted in positive changes in the blood cell count, humoral immunity, and phagocytic activity impaired after the small bowel resection and blood loss. The use of an anolyte disinfectant (liquid with positive ORP+710-770 mV) prevented bacterial contamination of the surgical wound. The obtained findings proved that the catholyte had a positive effect on humoral immunity and healing processes in the anastomotic zone. Furthermore, the anolyte prevented the development of purulent complications and inflammation in the area of the surgical wound, and therefore, promoted the healing processes.
کلیدواژه‌ها
Anolyte؛ Catholyte؛ Immunity؛ Intestinal anastomosis؛ Oxidoreduction potential (ORP)
سایر فایل های مرتبط با مقاله
مراجع
  1. Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J, Kalantar-Zadeh K, et al. Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int. 2013;84(6):1096-107.
  2. Scott M, Baldini G, Fearon K, Feldheiser A, Feldman L, Gan T, et al. Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 1: pathophysiological considerations. Acta Anaesthesiol Scand. 2015;59(10):1212-31.
  3. Aider M, Gnatko E, Benali M, Plutakhin G, Kastyuchik A. Electro-activated aqueous solutions: theory and application in the food industry and biotechnology. Innov Food Sci Emerg Technol. 2012;15:38-49.
  4. Кошелев П, Глухов А, Расчепеев Д, Остроушко А. Method of Treatment Posttraumatic Synovitis Using Aqueous Anolyte and Catholyte. J Exp Clin Surg. 2015;8(4):364-8.
  5. Wilcoxon F. Individual comparisons by ranking methods. Breakthroughs in statistics: Springer; 1992. p. 196-202.
  6. Yang Y-X, Lewis JD, editors. Prevention and treatment of stress ulcers in critically ill patients. Semin Gastrointest Dis; 2003;14(1):11-9.
  7. Gordy S, Kozar RA. Metabolism in the Trauma Patient. Surgical Metabolism: Springer; 2014. p. 97-109.
  8. Mahdy T, Schou C. Efficacy of single anastomosis sleeve ileal (SASI) bypass for type-2 diabetic morbid obese patients: Gastric bipartition, a novel metabolic surgery procedure: A retrospective cohort study. Int J Surg. 2016;34:28-34.
  9. Koivusalo AI, Sistonen SJ, Lindahl HG, Rintala RJ, Pakarinen MP. Long-term outcomes of oesophageal atresia without or with proximal tracheooesophageal fistula–gross types A and B. J Pediatr Surg. 2017;52(10):1571-5.
  10. Lázár G, Kaszaki J, Ábrahám S, Horváth G, Wolfárd A, Szentpáli K, et al. Thoracic epidural anesthesia improves the gastric microcirculation during experimental gastric tube formation. Surgery. 2003;134(5):799-805.
  11. King JA, Underwood FE, Panaccione N, Quan J, Windsor JW, Kotze PG, et al. Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development. Lancet Gastroenterol Hepatol. 2019;4(4):287-95.
  12. Levy AD, Murakata LA, Abbott RM, Rohrmann Jr CA. From the archives of the AFIP: benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Radiographics. 2002;22(2):387-413.
  13. Vuksic T, Zoricic I, Brcic L, Sever M, Klicek R, Radic B, et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat. Surg Today. 2007;37(9):768-77.
  14. Luján JJ, Németh ZH, Barratt-Stopper PA, Bustami R, Koshenkov VP, Rolandelli RH. Factors influencing the outcome of intestinal anastomosis. Am Surg. 2011;77(9):1169-75.
  15. Lassen K, Revhaug A. Early oral nutrition after major upper gastrointestinal surgery: why not? Curr Opin Clin Nutr Metab Care. 2006;9(5):613-7.
  16. Oetzmann von Sochaczewski C, Lindner A, Heimann A, Balus A, Patel VH, Harrison MR, et al. Beyond magnamosis: a method to test sutureless esophageal anastomotic devices in living swine by creating an esophageal bypass loop for natural oral nutrition. J Laparoendosc Adv Surg Tech. 2019;29(6):852-5.
  17. Lewis SJ, Andersen HK, Thomas S. Early enteral nutrition within 24 h of intestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. J Gastrointest Surg. 2009;13(3):569-75.
  18. Nelson R, Tse B, Edwards S. Systematic review of prophylactic nasogastric decompression after abdominal operations. J Br Surg. 2005;92(6):673-80.
  19. Silva TL, Maria de Lourdes S, Ferreira FR, Santos DC, Amatore C, Goulart MO. Quinone-based molecular electrochemistry and their contributions to medicinal chemistry: a look at the present and future. Curr Opin Electrochem. 2020;24:79-87.
  20. Zaritzky M, Ben R, Johnston K. Magnetic gastrointestinal anastomosis in pediatric patients. J Pediatr Surg. 2014;49(7):1131-7.
  21. Prilutsky V, Bakhir V. Electrochemically activated water: anomalous properties, mechanism of biological action. M, VNIIIMT. 1997.
  22. Sung JJ, Tsoi KK, Ma TK, Yung M-Y, Lau JY, Chiu PW. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol. 2010;105(1):84-9.
  1. Thantsha MS. Electrochemically activated water as an environmentally safe disinfectant: University of Pretoria; 2006.
  2. You X-y, Chai L-y, Wang Y-y, Su Y-r, Na Z, Shu Y-d. Regeneration of activated carbon adsorbed EDTA by electrochemical method. rans. Nonferrous Met Soc China. 2013;23(3):855-60.
  3. Lau JY, Yu Y, Tang RS, Chan HC, Yip H-C, Chan SM, et al. Timing of endoscopy for acute upper gastrointestinal bleeding. N Engl J Med. 2020;382(14):1299-308.
  4. Duong V, Tarantola A, Ong S, Mey C, Choeung R, Ly S, et al. Laboratory diagnostics in dog-mediated rabies: an overview of performance and a proposed strategy for various settings. Int J Infect Dis. 2016;46:107-14.
27.          Scott-Coombes D, Whawell S, Vipond M, Thompson J. Human intraperitoneal fibrinolytic response to elective surgery. J Br Surg. 1995;82(3):414-7.

آمار
تعداد مشاهده مقاله: 1,278
تعداد دریافت فایل اصل مقاله: 2,360


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب