اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,049
تعداد مقالات34,082
تعداد مشاهده مقاله46,509,441
تعداد دریافت فایل اصل مقاله77,562,709
Khandia, R, Puranik, N, Bhargava, D, Lodhi, N, Gautam, B, Dhama, K. (1400). Wound Infection with Multi-Drug Resistant Clostridium Perfringens: A Case Study. سامانه مدیریت نشریات علمی, 76(5), 1565-1573. doi: 10.22092/ari.2021.355985.1757
R Khandia; N Puranik; D Bhargava; N Lodhi; B Gautam; K Dhama. "Wound Infection with Multi-Drug Resistant Clostridium Perfringens: A Case Study". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1565-1573. doi: 10.22092/ari.2021.355985.1757
Khandia, R, Puranik, N, Bhargava, D, Lodhi, N, Gautam, B, Dhama, K. (1400). 'Wound Infection with Multi-Drug Resistant Clostridium Perfringens: A Case Study', سامانه مدیریت نشریات علمی, 76(5), pp. 1565-1573. doi: 10.22092/ari.2021.355985.1757
Khandia, R, Puranik, N, Bhargava, D, Lodhi, N, Gautam, B, Dhama, K. Wound Infection with Multi-Drug Resistant Clostridium Perfringens: A Case Study. سامانه مدیریت نشریات علمی, 1400; 76(5): 1565-1573. doi: 10.22092/ari.2021.355985.1757

Wound Infection with Multi-Drug Resistant Clostridium Perfringens: A Case Study

Archives of Razi Institute
مقاله 48، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1565-1573    اصل مقاله (495.04 K)
نوع مقاله: Case Study
شناسه دیجیتال (DOI): 10.22092/ari.2021.355985.1757
نویسندگان
R Khandia* 1؛ N Puranik1؛ D Bhargava1؛ N Lodhi1؛ B Gautam1؛ K Dhama2
1Department of Biochemistry and Genetics, Barkatullah University, Bhopal 462026 MP, India
2Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India
چکیده
Wound infections are among public health problems worldwide. However, progress has been made in improving surgical techniques and antibiotic treatments. Misuse/overuse of antibiotics to prevent and treat bacterial infections eventually leads to increased bacterial resistance with rising incidences of multi-drug resistant (MDR) bacterial strains. The wider dissemination of antibiotics may ultimately result in ineffectiveness to antibiotic therapy, thereby complicating/graving the outcome of a patient. In the present study, a 60-year-old male patient having wound infection with MDR bacterium that ultimately required surgical amputation of the toe was investigated. For the confirmation of MDR bacterium, two culture media viz., MacConkeyAgar and Mueller Hinton Agar media were used. The sensitivity of the isolated strain for various antibiotics was tested using the disc diffusion method. The wound sample was found positive for Gram-positive bacterium that was identified as Clostridium perfringens. The bacterium was screened for 40 antibiotics, and among all the antibiotics, it was found sensitive for only Piperacillin/Tazobactam antibiotic combination. C. perfringens bacterium caused the gas gangrene in the infected wound part of the patient. Amputation of the gangrene –affected foot part was performed by surgery, and with good medical care, the person recovered fast. To the best of our knowledge, this is the first-ever report of MDRC. perfringens single isolate  harboring resistance against at least 40 antibiotics tested. More research is needed to develop really new and effective medicines that do not cross-react with antibiotics now in use and have robust activity against MDR organisms.
کلیدواژه‌ها
Clostridium perfringens؛ Gas gangrene؛ Multi-drug resistance؛ Wound
سایر فایل های مرتبط با مقاله
مراجع
  1. Tiwari R, Dhama K. Antibiotic resistance: A frightening health dilemma. Am J Pharmacol Toxicol. 2014;9(3):174–6.
  2. Jean SS, Gould IM, Lee W Sen, Hsueh PR. New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship. Drugs. 2019;79(7):705–14.
  3. Voulgaris GL, Voulgari ML, Falagas ME. Developments on antibiotics for multidrug resistant bacterial Gram-negative infections. Expert Rev Anti Infect Ther. 2019;17(6):387–401.
  4. Terreni M, Taccani M, Pregnolato M. New antibiotics for multidrug-resistant bacterial strains: Latest research developments and future perspectives. Molecules. 2021;26(9).
  5. Ghosh C, Sarkar P, Issa R, Haldar J. Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance. Trends Microbiol. 2019;27(4):323–38.
  6. Majumder MAA, Rahman S, Cohall D, Bharatha A, Singh K, Haque M, et al. Antimicrobial stewardship: Fighting antimicrobial resistance and protecting global public health. Infect Drug Resist. 2020;13:4713–38.
  7. Mohammad IS, He W, Yin L. Insight on multidrug resistance and nanomedicine approaches to overcome mdr. Crit Rev Ther Drug Carrier Syst. 2020;37(5):473–509.
  8. Khan AA, Manzoor KN, Sultan A, Saeed M, Rafique M, Noushad S, et al. Pulling the brakes on fast and furious multiple drug-resistant (MDR) bacteria. Int J Mol Sci. 2021;22(2):1–40.
  9. Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001;14:244–69.
  10. Negut I, Grumezescu V, Grumezescu AM. Treatment Strategies for Infected Wounds. Molecule. 2018;23(9).
  11. Kim Hyonsurk. Wound infection. Ann R Coll Surg Engl. 2019;46(5):484–5.
  12. Bessa LJ, Fazii P, Di Giulio M, Cellini L. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: Some remarks about wound infection. Int Wound J. 2015 ;12(1):47–52.
  13. Meredith TA. Chapter 133 - Vitrectomy for Infectious Endophthalmitis. In: Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP, editors. Retina (Fourth Edition). Edinburgh: Mosby; 2006. p. 2255-75.
  14. Preseau T, Deviendt J, Duttman R, Attou R, Franck D, Claeys R, et al. Clostridium perfringens in gas gangrene: Still a smoked gun! J Transl Intern Med. 2020;8(1):54–6.
  15. Mehdizadeh Gohari I, M AN, Li J, Shrestha A, Uzal F, B AM. Pathogenicity and virulence of Clostridium perfringens. Virulence. 2021;12(1):723-53.
  16. García S, Vidal JE, Heredia N, Juneja VK. Clostridium perfringens. Food Microbiol.2019. p. 513-40.
  17. Everhart JS, Altneu E, Calhoun JH. Medical comorbidities are independent preoperative risk factors for surgical infection after total joint arthroplasty. Clin Orthop Relat Res. 2013;471(10):3112-9.
  18. Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general principles and contemporary practices. Clin Infect Dis. 2009;49(11):1749-55
  19. Lusis AJ. Atherosclerosis. Nature. 2000;407:233–41.
  20. Pirvanescu H, Balasoiu M, Ciurea M, Balasoiu A, Manescu R. Wound infections with multi-drug resistant bacteria. Chirurgia. 2014;109(1):73-9.
  21. Ganguly S, Wakchaure R, Para P, Praveen P, Sahoo S, Mahajan T, et al. Mdr Bacteria: A Review of Immense Relevance in Veterinary Microbiology. JBINO. 2016;5:319-24.
  22. C Cillóniz C, Dominedò C, Torres A. Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia. Critical Care. 2019;23(1):79.
  23. Nikaido H. Multidrug resistance in bacteria. Annu Rev Biochem. 2009;78: 119–46.
  24. Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309-18.
  25. Beardmore RE, Peña-Miller R, Gori F, Iredell J, Barlow M. Antibiotic cycling and antibiotic mixing: Which one best mitigates antibiotic resistance?.Mol Biol Evol. 2017;34(4):802–17.
  26. Kollef MH. Is antibiotic cycling the answer to preventing the emergence of bacterial resistance in the intensive care unit? Clin Infect Dis. 2006;43(2):82-8.
  27. Serra-Burriel M, Keys M, Campillo-Artero C, Agodi A, Barchitta M, Gikas A, et al. Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis. PLoS One. 2020;15(1):1–14.
  28. Akhi MT, Asl SB, Pirzadeh T, Naghili B, Yeganeh F, Memar Y, et al. Antibiotic sensitivity of clostridium perfringens isolated from faeces in Tabriz, Iran. Jundishapur J Microbiol. 2015;8(7):6–9.
  29. van der Woude B, Berkhout J, van Basten JP, Schouten J. Clostridium perfringens: A rare cause of postoperative septic shock. Netherlands J Crit Care. 2018;26(4):147–9.
  30. Tsutsumi Y. Pathology of Gangrene. In: Pathogenic Bacteria. IntechOpen; 2020.
  31. Yadav JP, Das SC, Dhaka P, Vijay D, Kumar M, Mukhopadhyay AK, et al. Molecular characterization and antimicrobial resistance profile of Clostridium perfringens type A isolates from humans, animals, fish and their environment. Anaerobe. 2017;47:120–4.
  32. Hmood AM, Al-Shukri MSM, Al-Charrakh AH. Molecular detection and antimicrobial resistance of clostridium perfringens isolated from diabetic patients and bullet wounds. J Appl Biol Biotechnol. 2019;7(1):54–9.
  33. Wang Y, Qian P-Y. Conservative Fragments in Bacterial 16S rRNA Genes and Primer Design for 16S Ribosomal DNA Amplicons in Metagenomic Studies. PLoS One. 2009;4(10):e7401.
  34. Niimi M, Ikeda Y, Kan S, Takami H. Gas gangrene in patient with atherosclerosis obliterans. Asian Cardiovasc Thorac Ann. 2002;10(2):178–80.
  1. Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJC, Gorbach SL, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59(2).
  2. Stevens DL, Laine BM, Mitten JE. Comparison of single and combination antimicrobial agents for prevention of experimental gas gangrene caused by Clostridium perfringens. Antimicrob Agents Chemother. 1987;31(2):312–6.
  3. Stevens DL, Maier KA, Mitten JE. Effect of antibiotics on toxin production and viability of Clostridium perfringens. Antimicrob Agents Chemother. 1987;31(2):213-8.
  4. Determann C, Walker CA. Clostridium perfringens gas gangrene at a wrist intravenous line insertion. BMJ Case Rep. 2013;2–4.
آمار
تعداد مشاهده مقاله: 2,170
تعداد دریافت فایل اصل مقاله: 3,176


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب