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Morozova, E. N, Morozov, V. N, Tverskoi, A. V, Perepelkina, S. N, Konshina, V. P. (1400). Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine after Imofan Treatment in Immunosuppressed Rats. سامانه مدیریت نشریات علمی, 76(4), 879-886. doi: 10.22092/ari.2021.355816.1724
E. N Morozova; V. N Morozov; A. V Tverskoi; S. N Perepelkina; V. P Konshina. "Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine after Imofan Treatment in Immunosuppressed Rats". سامانه مدیریت نشریات علمی, 76, 4, 1400, 879-886. doi: 10.22092/ari.2021.355816.1724
Morozova, E. N, Morozov, V. N, Tverskoi, A. V, Perepelkina, S. N, Konshina, V. P. (1400). 'Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine after Imofan Treatment in Immunosuppressed Rats', سامانه مدیریت نشریات علمی, 76(4), pp. 879-886. doi: 10.22092/ari.2021.355816.1724
Morozova, E. N, Morozov, V. N, Tverskoi, A. V, Perepelkina, S. N, Konshina, V. P. Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine after Imofan Treatment in Immunosuppressed Rats. سامانه مدیریت نشریات علمی, 1400; 76(4): 879-886. doi: 10.22092/ari.2021.355816.1724

Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine after Imofan Treatment in Immunosuppressed Rats

Archives of Razi Institute
مقاله 17، دوره 76، شماره 4، آذر و دی 2021، صفحه 879-886    اصل مقاله (838.5 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355816.1724
نویسندگان
E. N Morozova* ؛ V. N Morozov؛ A. V Tverskoi؛ S. N Perepelkina؛ V. P Konshina
Belgorod State University, Belgorod, Russia
چکیده
Diffuse nodular lymphoid hyperplasia is a rare gastrointestinal disease that can be diagnosed by multiple nodules in the small intestine, large intestine, or both. Immunodeficiency and infections are the common situations that lead to the diffusion of nodular lymphoid hyperplasia. For instance, Giardia lamblia and Helicobacter pylori are the major pathogens leading to this disorder. Diffuse nodular lymphoid hyperplasia leads to allergic reactions, immunodeficiency, and autoimmune diseases. Imunofan-RDKVYR Peptide-is a potential agent in regenerative medicine. The present study aimed to investigate morphological features of the aggregated lymphoid nodules of the small intestine after the Imunofan (IM) administration following Cyclophosphamide-induced immunosuppression. In total, 72 Wistar male rats were randomly divided into two groups (n=36). Group I was considered the control group, and group II was subjected to intramuscular injections (needle 21 G) of0.2 ml of normal saline following the Cyclophosphamide-induced immunosuppression on the2nd, 4th, 6th, 8th, and 10th days of the experiment. The animals in group II were injected with Cyclophosphamide at a dose of 200 mg/kg bodyweight to induce immunosuppression. The animals in the experimental group (n=36) were subjected to intramuscular injections (needle 21 G) of the 0.2 ml IM at a dose of 0.7μg/kg body weight on the 2nd, 4th, 6th, 8th, 10th days of the experiment. The results of the study indicated that on the 7th day in group II, the length and width of the aggregated lymphoid nodules increased, as well as the height and width of the lymphoid nodules and internodular zones as structural components of the lymphoid formations in the small intestine. In group I, by the 30th day of the experiment, the linear dimensions of the aggregated lymphoid nodules exceeded, but to a lesser extent than on the 7th day of the experiment which explains the ability of IM to neutralize the effects of Cyclophosphamide.  It should also be noted that the IM was performed to regenerate damaged cells which helped maintain the population of lymphocytes in the limb and led to an increase in linear dimensions (length and width) not only between the joint but also in the lymph nodes.
کلیدواژه‌ها
Aggregated lymphoid nodules؛ Cyclophosphamide؛ Imunofan؛ Rats؛ Small intestine
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مراجع
    1. Colao A, Muscogiuri G, Piscitelli P. Environment and health: not only cancer. Int J Environ Res Public Health; 2016; 13(7):724.
    2. Danilova Z. Ecological Situation and Risks For Public Health. 2019;3(81):176-9.
    3. Hryn VH, Kostylenko YP, Bilash VP, Ryabushko OB. Microscopic structure of albino rats’ small intestine. Wiad Lek. 2019;72: 733-8.
    4. Haley PJ. The lymphoid system: a review of species differences. J Toxicol Pathol. 2017;30(2):111-23.
    5. Albuquerque A. Nodular lymphoid hyperplasia in the gastrointestinal tract in adult patients: A review. World J Gastrointest Endosc. 2014;6(11):534.
    6. Choi JH, Han DS, Kim J, Yi K, Oh Y-H, Kim Y. Diffuse nodular lymphoid hyperplasia of the intestine caused by common variable immunodeficiency and refractory giardiasis. Intern Med J 2017;56(3):283-7.
    7. Reboldi A, Cyster JG. Peyer's patches: organizing B‐cell responses at the intestinal frontier. Immunol Rev. 2016;271(1):230-45.
    8. Zgair A, Wong JCM, Gershkovich P. Targeting immunomodulatory agents to the gut-associated lymphoid tissue. Neuro-Immuno-Gastroenterology: Springer; 2016.237-61.
    9. Khaitov R. Immunomodulators: Myths and Reality. Immunologiya. 2020;41(2):101-6.
    10. Kim WH, Lillehoj HS. Immunity, immunomodulation, and antibiotic alternatives to maximize the genetic potential of poultry for growth and disease response. Anim Feed Sci Technol. 2019;250:41-50.
    11. Ahlmann M, Hempel G. The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy. Cancer Chemother Pharmacol. 2016;78(4):661-71.
    12. Teles KA, Medeiros-Souza P, Lima FAC, Araújo BGd, Lima RAC. Cyclophosphamide administration routine in autoimmune rheumatic diseases: a review. Rev Bras Reumatol. 2017;57:596-604.
    13. Sawicka J, Dzierżyńska M, Wardowska A, Deptuła M, Rogujski P, Sosnowski P, et al. Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair. Molecules. 2020;25(12):2884.
    14. Kashchenko SA, ON. P. Experimental ultramicroscopic examination of the right axillary lymph nodes of rats. 2011:80-2.
    15. Muhamadeeva OR, Hismatullina ZR, YUA M. The effectiveness of the immunomodulator "Imunofan" in the complex treatment of patients with zooanthroponous trichophytosis. Vestnik sovremennoj klinicheskoj mediciny. 2014;7(1):31-4.
    16. MR. S. Immune structures of the digestive organs (Functional anatomy). Medicina. 1987.
    17. Reynolds ES. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963;17(1):208-12.
    18. Kashchenko SA, Morozova OM, Petіzіna OM, Zolotarevs'ka MV, MЄ. A. A method of detecting the immune system of the small intestine and lymph nodes among the surrounding tissues. 2012.
    19. Kvaratskheliya A, Klochkova S, Nikityuk D, Alekseeva N. Morphological characteristics of the thymus and spleen under different factors of origin. Zhurnal anatomii i gistopatologii. 2016;5(3):77-83.
    20. Nor-Satinati S, Zuki A, Zamri-Saad M, Awang-Hazmi A, Po SP. The Response of Gut Associated Lymphoid Tissues (GALT) Following Intranasal Administration of P. Multocida B2 in Rats. J Anim Vet Adv. 2006. 
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