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Faeqali Jan, M, Muneer Al-Khafaji, H, Hasan Al-Saadi, B, Aneed Al-Saedi, M. K. (1400). Assessment of Interleukin-8 in Bronchial Asthma in Iraq. سامانه مدیریت نشریات علمی, 76(4), 913-923. doi: 10.22092/ari.2021.355733.1712
M Faeqali Jan; H Muneer Al-Khafaji; B Hasan Al-Saadi; M. K Aneed Al-Saedi. "Assessment of Interleukin-8 in Bronchial Asthma in Iraq". سامانه مدیریت نشریات علمی, 76, 4, 1400, 913-923. doi: 10.22092/ari.2021.355733.1712
Faeqali Jan, M, Muneer Al-Khafaji, H, Hasan Al-Saadi, B, Aneed Al-Saedi, M. K. (1400). 'Assessment of Interleukin-8 in Bronchial Asthma in Iraq', سامانه مدیریت نشریات علمی, 76(4), pp. 913-923. doi: 10.22092/ari.2021.355733.1712
Faeqali Jan, M, Muneer Al-Khafaji, H, Hasan Al-Saadi, B, Aneed Al-Saedi, M. K. Assessment of Interleukin-8 in Bronchial Asthma in Iraq. سامانه مدیریت نشریات علمی, 1400; 76(4): 913-923. doi: 10.22092/ari.2021.355733.1712

Assessment of Interleukin-8 in Bronchial Asthma in Iraq

Archives of Razi Institute
مقاله 21، دوره 76، شماره 4، آذر و دی 2021، صفحه 913-923    اصل مقاله (749 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355733.1712
نویسندگان
M Faeqali Jan* 1؛ H Muneer Al-Khafaji1؛ B Hasan Al-Saadi2؛ M. K Aneed Al-Saedi3
1Department of Applied Science, University of Technology, Baghdad, Iraq
2Institute of Genetic Engineering and Biotechnologies for Post Graduate Studies, University of Baghdad, Baghdad, Iraq
3Iraqi Hereditary company, Baghdad, Iraq
چکیده
It has been approved that neutrophils are responsible for many inflammatory lung diseases, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma. It is well documented that the CXC chemokine interleukin-8 (IL-8) plays a key role as a potent neutrophil recruiting and activating factor. Asthma is one of the most common major non-contagious diseases and has a substantial impact on the patient’s quality of life. The current evidence suggests that asthma is a complex multifactorial disorder, and its etiology is increasingly attributed to interactions between genetic susceptibility, host factors, and environmental exposures. IL-8 plays an important role in respiratory diseases and is a known regulator of pulmonary inflammation and immunity, induced phagocytosis, and promoted angiogenesis. This study aimed to investigate the IL-8 gene expression in blood samples of bronchial asthma patients. Therefore, the blood samples were taken from two groups of participants, including the group of patients with asthma (n=100) in the age range of20-61years and the group of healthy individuals (n=50).The obtained results indicated that the expression of IL-8 mRNA in the group of asthma patients was three times higher than that in the group of healthy individuals. Therefore, it is suggested that the antagonism of IL-8 could be a potent therapeutic strategy in the treatment of asthma.
کلیدواژه‌ها
Bronchial asthma؛ Gene expression؛ IL-8؛ qRT-PCR؛ RT-PCR
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مراجع
  1. National Heart LaBI. Guidelines for the diagnosis and management of asthma (EPR-3). Bethesda, MD: NHLBI. 2007.
  2. Mirabelli MC, Vaidyanathan A, Flanders WD, Qin X, Garbe P. Outdoor PM2. 5, ambient air temperature, and asthma symptoms in the past 14 days among adults with active asthma. Environ Health Perspect. 2016;124(12):1882-90.
  3. Al-Khafaji H. Gene Expression Bcl-2 Gene in Cancer of Brest in Iraqi population. Eng Technol J. 2017;35(2 Part B):119-25.
  4. Cockcroft DW, editor Environmental causes of asthma. Seminars in respiratory and critical care medicine; 2018: Thieme Medical Publishers.
  5. Isogai S, Niwa Y, Yatsuya H, Hayashi M, Yamamoto N, Okamura T, et al. Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma. Allergol Int. 2017;66(2):360-2.
  6. Morales DR, Lipworth BJ, Donnan PT, Jackson C, Guthrie B. Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study. BMC Med. 2017;15(1):1-9.
  7. Badnjević A, Gurbeta L, Cifrek M, Marjanovic D, editors. Classification of asthma using artificial neural network. 2016 39th International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO); 2016: IEEE.
  8. Stern J, Pier J, Litonjua AA, editors. Asthma epidemiology and risk factors. Seminars in immunopathology; 2020: Springer.
  9. Rasmussen SM, Hansen ESH, Toennesen LL, Pitzner-Fabricius A, Hansen NB, Backer V. Diet and Exercise: A Novel Cure for Asthma?-A Short Communications on a Non-Pharmacological Strategy. Am J Phys Med Rehabil. 2020;2(1).
  10. Jabir MS, Sulaiman GM, Taqi ZJ, Li D. Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection. Microbes Infect 2018;20(2):89-100.
  11. He Q, Shi X, Zhou B, Teng J, Zhang C, Liu S, et al. Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke. Mol Immunol. 2018;101:440-9.
  12. Meniailo ME, Malashchenko VV, Shmarov VA, Gazatova ND, Melashchenko OB, Goncharov AG, et al. Interleukin-8 favors pro-inflammatory activity of human monocytes/macrophages. Int Immunopharmacol. 2018;56:217-21.
  13. Mohammed AA, Abdulhadi SS. Evaluation of the Concentration of Ubiquitin C Protein (UBC) in Patients of Lung Cancer and Comparing with Healthy Subjects. Eng Technol J. 2020;38(2B):61-5.
  14. Marinello W, Feng L, Allen TK. Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells. Front Physiol. 2020;11:900.
  15. Bi H, Zhang Y, Wang S, Fang W, He W, Yin L, et al. Interleukin‑8 promotes cell migration via CXCR1 and CXCR2 in liver cancer. Oncol Lett. 2019;18(4):4176-84.
  16. Xu M-H, Yuan F-L, Wang S-J, Xu H-Y, Li C-W, Tong X. Association of interleukin-18 and asthma. Inflammation. 2017;40(1):324-7.
  17. Yang XD, Corvalan JR, Wang P, Roy CMN, Davis CG. Fully human anti‐interleukin‐8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states. J Leukoc Biol. 1999;66(3):401-10.
  18. Zarafshani M-K, Shahmohammadi A, Vaisi-Raygani A, Bashiri H, Yari K. Association of interleukin-8 polymorphism (+ 781 C/T) with the risk of ovarian cancer. Meta Gene. 2018;16:165-9.
  19. Chi S, Xue J, Li F, Zhu C, Yu Y, Li H, et al. Correlation of serum soluble interleukin-7 receptor and anti-C1q antibody in patients with systemic lupus erythematosus. Autoimmune Dis. 2016;2016.
  20. Li P, Du J, Goodier JL, Hou J, Kang J, Kazazian HH, et al. Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. Nucleic Acids Res. 2017;45(8):4619-31.
  21. Li S, Tian Y, Wu K, Ye Y, Yu J, Zhang J, et al. Modulating plant growth–metabolism coordination for sustainable agriculture. Nature. 2018;560(7720):595-600.
  22. Abed SA, Al-Khafaji HM. Design Of Primer And Probe To Detect SNP Rs 1892901 In Fosl-1Gene In Different Types Of Cancer In Iraqi Population. Syst Rev Pharm. 2021;12(1):296-300.
  23. Wei Y, Hu W, Wang Q, Zeng H, Li X, Yan Y, et al. Identification, transcriptional and functional analysis of heat‐shock protein 90s in banana (M usa acuminata L.) highlight their novel role in melatonin‐mediated plant response to F usarium wilt. J Pineal Res. 2017;62(1):e12367.
  1. Yang T-b, Liu J, Yuan L-y, Zhang Y, Li D-q, Agnarsson I, et al. Molecular identification of spiders preying on Empoasca vitis in a tea plantation. Sci Rep. 2017;7(1):1-10.
  2. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3(6):1101-8.
  3. Cary N. Statistical analysis system, User's guide. Statistical. Version 9. SAS Inst Inc USA. 2012.
  4. Mohammed WH. Effect of Honey on Mice in Vitro Fertilization (IVF). Eng Technol J. 2014;32(1):107-13.
  5. Zein JG, Dweik RA, Comhair SA, Bleecker ER, Moore WC, Peters SP, et al. Asthma is more severe in older adults. PLoS One. 2015;10(7):e0133490.
  6. Al-Khafaji, M H. Detection one of DNA repair gene for lung cancer in sample of Iraqi patients. Iraqi J Biotechnol. 2017;16(3).
  7. Barber RD, Harmer DW, Coleman RA, Clark BJ. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics. 2005;21(3):389-95.
  8. Lambrecht BN, Hammad H, Fahy JV. The cytokines of asthma. Immunity. 2019;50(4):975-91.
  9. Zhang J, Bai C. Elevated serum interleukin-8 level as a preferable biomarker for identifying uncontrolled asthma and glucocorticosteroid responsiveness. Tanaffos. 2017;16(4):260.
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