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Amirkhani, Rezvan, Farzaei, Mohammad Hosein, Ghanbari, Elham, Khazaei, Mozafar, Aneva, Ina. (1401). Cichorium intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study. سامانه مدیریت نشریات علمی, 11(1), 111-118. doi: 10.22092/jmpb.2021.354093.1347
Rezvan Amirkhani; Mohammad Hosein Farzaei; Elham Ghanbari; Mozafar Khazaei; Ina Aneva. "Cichorium intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study". سامانه مدیریت نشریات علمی, 11, 1, 1401, 111-118. doi: 10.22092/jmpb.2021.354093.1347
Amirkhani, Rezvan, Farzaei, Mohammad Hosein, Ghanbari, Elham, Khazaei, Mozafar, Aneva, Ina. (1401). 'Cichorium intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study', سامانه مدیریت نشریات علمی, 11(1), pp. 111-118. doi: 10.22092/jmpb.2021.354093.1347
Amirkhani, Rezvan, Farzaei, Mohammad Hosein, Ghanbari, Elham, Khazaei, Mozafar, Aneva, Ina. Cichorium intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study. سامانه مدیریت نشریات علمی, 1401; 11(1): 111-118. doi: 10.22092/jmpb.2021.354093.1347

Cichorium intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study

Journal of Medicinal Plants and By-products
دوره 11، شماره 1، تیر 2022، صفحه 111-118    اصل مقاله (445.15 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22092/jmpb.2021.354093.1347
نویسندگان
Rezvan Amirkhani1؛ Mohammad Hosein Farzaei2؛ Elham Ghanbari3؛ Mozafar Khazaei* 3؛ Ina Aneva4
1Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, Bulgaria
چکیده
Oxymetholone (OM) is a 17-α-alkylated anabolic-androgenic steroid used at low doses for the treatment of diseases such as anemia and osteoporosis. The present study aimed to evaluate the hepatoprotective effect of Cichorium intybus L. (Chicory) extract on OM-induced changes in liver enzymes, serum antioxidant status and liver tissue in rats. 42 Wistar rats were divided into 6 groups (n=7): control group (0.5 ml distilled water), OM group (5 mg/kg), C. intybus groups (100 or 200 mg/kg), and OM+C. intybus groups (5 mg/kg OM+100 or 200 mg/kg extracts). After two weeks, the animals were weighed and serum was separated to assay liver enzymes [aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatases (ALP)], nitric oxide (NO) and total antioxidant capacity (TAC). The liver was separated, weighed, fixed and stained with the hematoxylin-eosin method. OM significantly increased NO and liver enzyme (AST, ALP, ALP) concentrations, and significantly decrease serum TAC, animal and liver weights (P<0.05) and changed liver histology. Different concentrations of C. intybus extract (100 or 200 mg/kg) improved these OM-induced changes significantly (P<0.05). Chicory reversed serum biochemical and histological changes due to OM consumption.
کلیدواژه‌ها
Liver؛ Cichorium intybus؛ Oxymetholone؛ Nitric oxide؛ Antioxidant
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