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An Overview of the Most Important Medicinal Plants that Affect Hypertension and their Antihypertensive Mechanism | ||
| Journal of Medicinal plants and By-products | ||
| دوره 10، Special، تیر 2021، صفحه 1-8 اصل مقاله (174.57 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2020.351544.1248 | ||
| نویسندگان | ||
| Gholam Basati1؛ Fatemeh Mehrabi Rad2، 3؛ Arash Momeni Safarabadi2، 3؛ Pegah Shakib4؛ Mehrnoosh Sedighi* 5؛ Mostafa Cheraghi5 | ||
| 1Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran | ||
| 2Lorestan University of Medical Sciences, Khorramabad, Iran | ||
| 3Health Nursing, Lorestan University of Medical Sciences, Khorramabad, Iran | ||
| 4Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran | ||
| 5Razi Herbal Medicines Research Center & Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran | ||
| چکیده | ||
| Despite the increased awareness about high blood pressure, it remains a major cause of morbidity and mortality in the community. Medication and high blood pressure can be treated with medication and non-medication. The high prevalence of high blood pressure around the world and development of serious and dangerous complications this disease a major health problem in all societies and is a major cause of cardiovascular disease. Concerns about the side effects of chemical drugs lead to misuse of medications, intolerance to patients and consequently, impaired control of the disease. That's why today there is a new approach to medicinal plants and a lot of research is being done on medicinal plants. The purpose of the present study is investigation of plants and provides the mechanism of action of the most effective medicinal plants in the treatment of hypertension. This paper examines the use of electronic search in articles published in various Internet databases and reference books on the mechanism of action of various plants in the treatment of hypertension by affecting the molecular mechanisms involved in the disease. According to the results of some medicinal plants such as Camellia sinensis (L.) Kuntze, Berberis vulgaris L., Rosa × damascena Herrm., Punica granatum L., Olea europaea L., Teucrium polium L., Lavandula angustifolia Mill., Urtica Dioica L., Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L., Allium sativum L. and Juglans regia L. are the most important medicinal plants affecting high blood pressure. Studies have shown that medicinal plants with various mechanisms such as vasodilation, production of nitric oxide (NO), calcium channel blockers, increased potassium, inhibition of renin-angiotensin pathway, and activation of intracellular CGMP and expansion of vasodilator effect to hypertension treatment. | ||
| کلیدواژهها | ||
| Hypertension؛ Medicinal Plants؛ Molecular Mechanisms؛ Drug | ||
| مراجع | ||
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1. Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens. 2004;22:9-11. 2. Rasmussen CB, Glisson JK, Minor DS. Dietary supplements and hypertension: potential benefits and precautions. J Clin Hypertens. 2012;14:467-471.3. Cheng TO. All teas are not created equal: the Chinese green tea and cardiovascular health. Int J Cardiol. 2006;108:301-8. 4. Kumar N, Calhoun DA, Dudenbostel T. Management of patients with resistant hypertension: current treatment options. Integr Blood Press Contr. 2013;6:139. 5. Phinikaridou A, Andia ME, Lacerda S, Lorrio S, Makowski MR, Botnar RM. Molecular MRI of atherosclerosis. Molecules. 2013;18:14042-14069. 6. Cushman M, Arnold AM, Psaty BM, Manolio TA, Kuller LH, Burke GL, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation. 2005;112:25-31. 7. MazloomyMahmoodabad S, Agh Atabay R, Movahed M, Alizadeh S. Predictive control high blood pressure in patients with hypertension based on health belief model in Kerman in 2015. Tolooebehdasht. 2016;14:98-106. 8. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-223. 9. Sotodeh-Asl N, Neshat-Dust H, Kalantari M, Talebi H, Khosravi A. Comparison of effectiveness of two methods of hope therapy and drug therapy on the quality of life in the patients with essential hypertension. J Clin Psychol. 2010;2:1-5. 10. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison's principles of internal medicine: McGraw Hill. 2001. 11. Lilly LS, Braunwald E. Braunwald's heart disease: a textbook of cardiovascular medicine: Elsevier Health Sciences. 2012. 12. VII J. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright Jr JT, Roccella EJ. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. JAMA. 2003;289:2560-72. 13. Mazloomy Mahmoodabad SS, Tehrani H, Gholian-aval M, Gholami H, Nematy M. The effect of social class on the amount of salt intake in patients with hypertension. Blood Pressure. 2016;25:360-263. 14. Haghranjbar F, Shirzad M, Taghdisi MH, Sarami GR, Ahadi H. The mediating role of subjective-wellbeing in terms of perceived stress and hypertension. IJHEHP. 2016;4:50-57. 15. Khoshraftar RE, Ildarabadi E, BehnamE VH, Emami MZ. The effect of peer education on the mental aspect of quality of life of elderly patients with hypertension. J North Khorasan Univ Med Sci. 2016;7:585-595. 16. Sadeghi R, Mohseni M, Khanjani N. The effect of an educational intervention according to hygienic belief model in improving care and controlling among patients with hypertension. JRafsanjanUnivMedSci. 2014;13:383-94. 17. Goldansaz SM, Hakimi Meybodi MH, Mirhosseini A, Mirjalili MH. Essential Oil Composition of Salvia tebesana Bunge (Lamiaceae) from Iran. Rec Nat Prod. 2017;11:310-314.
18. Mosleh Arani A, Naderi M, Goldansaz S.M. Effect of Harvesting Time on Essential Oil Content and Composition of Thymbra spicata. J Med Plant By-prod. 2015;1:51-55.
19. Goldansaz SM, Jafarian Jeloudar Z, Safaeian R, Sonboli A. Eco-phytochemistry of Nepeta asterotricha Rech. f. (Case study: Deh Bala, Yazd). J Med Plant and By-pro. 2017;6:213-219.
20. Ghasemi Pirbalouti A, Firoznezhad M, Craker L, Akbarzadeh M. Essential oil compositions, antibacterial and antioxidant activities of various populations of Artemisia chamaemelifolia at two phenological stages. Revista Brasileira de Farmacog. 2013;23:861-869.
21. Goldansaz SM, et al. Study of essential oils compositions of three species of medicinal plants from ShirKooh mountain (Up village) on Yazd province. J Med Plan By-prod. 2014;2:187-191.
22. Cabrera C, Artacho R, Giménez R. Beneficial effects of green tea-a review. Journal of the American College of Nutrition. 2006;25:79-99. 23. Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S, Fujiwara H. Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Medica. 1999;65:381-3. 24. Ikram M. A review on the chemical and pharmacological aspects of genus Berberis. Planta medica. 1975;28:353-358. 25. Naĭdovich L, Trutneva E, Tolkachev O, Vasil'eva V. Chemical makeup of Soviet species of the Berberidaceae family. The interrelationship of chemical structure and pharmacological activity. Farmatsiia. 1976;25:33-38. 26. Chun Y, Yip T, Lau K, Kong Y, Sankawa U. A biochemical study on the hypotensive effect of berberine in rats. General Pharmacology: The Vascular System. Iran J Basic Med Sci. 1979;10:177-182. 27. Shamsi M, Abbasi N, Mohajer A, Hoseini M, Rafieian-Kopaei M. The most important native medicinal plants effective against cutaneous leishmaniasis in mouse. Int JLPR. 2018;8:1-P7. 28. Batooli H, Safaei-Ghomi J. Comparison of essential oil composition of flowers of three Rosa damascena Mill. genotypes from Kashan. J Med Plants. 2012;2:157-166. 29. Emad M GF RS. Khanjanzade R and Mohammadi Jozani S. Poone; Pharmacological Effects of Rosa Damascena Rosa damascena.IJBM. 2011;14:295-307. 30. Conrad P, Adams C. The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman–a pilot study. Complement Ther Clin Pract. 2012;18:164-168. 31. Uzunçakmak T, Alkaya SA. Effect of aromatherapy on coping with premenstrual syndrome: A randomized controlled trial. Complement Ther Med. 2018;36:63-7.
32. Hwang JH. The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension. Taehan Kanho Hakhoe Chi. 2006;36:1123-1134. 33. Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957-967. 34. de Nigris F, Williams-Ignarro S, Sica V, Lerman LO, D'Armiento FP, Byrns RE, et al. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res. 2007;73:414-423. 35. Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, et al. Effects of consumption of pomegranate juice on carotid intima–media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol. 2009;104:936-942. 36. Jurenka J. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008;13:128-44. 37. Aviram M, Dornfeld L, Kaplan M, Coleman R, Gaitini D, Nitecki S, et al. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res. 2002;28:49-62.
38. Farvid MS, Jalali M, Siassi F, Saadat N, Hosseini M. The impact of vitamins and/or mineral supplementation on blood pressure in type 2 diabetes. J Am Coll Nutr. 2004;23:272-9. 39. Zargari A. Medicinal plants 6 th ed. . Tehran university press. 1996:320-35. 40. Capretti G, Bonaconza E. Effects of infusions or decoctions of olive leaves (Olea europaea) on some physical constants of blood and components of metabolism. Giorn Clin Med. 1949. 30:630-642 41. Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla M. Vasodilator effect of olive leaf. Planta Medica. 1991;57:417-9. 42. Gharaibeh MN, Elayan HH, Salhab AS. Hypoglycemic effects of Teucrium polium. J Ethnopharmacol. 1988;24:93-9. 43. YAZDAN PR, Esmaeili MA, ASHRAFI HJ. Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: A histopathological examination. IBJ. 2005;9:81-85 44. Mosadegh M, Dehmoubed Sharifabadi A, Nasiri P, Esmaeili S, Naghibi F. The study of phytochemical, antifungal and antibacterial effects of teucrium polium and cichourium intybus. Sci J Kurdistan Univ Med Sci. 2002;7:1-6. 45. Vahdani M, Faridi P, Zarshenas MM, Javadpour S, Abolhassanzadeh Z, Moradi N, et al. Major compounds and antimicrobial activity of essential oils from five Iranian endemic medicinal plants. Pharmacogn J. 2011;3:48-53. 46. Gharb NMK, Omidi BF, Vakilzadeh G. Spasmolytic effect of Teucrium polium on virgin rat uterus. Iran J basic Med Sci. 2005;1:31-37 47. Zargari A. Medicinal plants. 4th ed. Tehran:. Tehran University Publications. 1988;2:210–2. 48. Hui L, He L, Huan L, XiaoLan L, AiGuo Z. Chemical composition of lavender essential oil and its antioxidant activity and inhibition against rhinitis-related bacteria. AJMR. 2010;4:309-313. 49. Tanida M NA, Shen J, Nakamura T, Nagai K. . Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats. . Neurosci letters. 2006;398:155-160. 50. Lis‐Balchin M, Hart S. Studies on the mode of action of the essential oil of LavenderLavandula angustifolia P. Miller Phytother Res : An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. Phytother Res. 1999;13:540-542. 51. Heitzer T, Finckh B, Albers S, Krohn K, Kohlschütter A, Meinertz T. Beneficial effects of α-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med. 2001;31:53-61. 52. Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. Phytomed. 2007;14:568-579. 53. Tahri A, Yamani S, Legssyer A, Aziz M, Mekhfi H, Bnouham M, et al. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol. 2000;73:95-100.
54. Stephens J, editor The politics of Muslim rage: Secular law and religious sentiment in late colonial India. History Workshop Journal; Oxford University Press. 2014. 55. Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, et al. Cardiovascular effects of Urtica dioica L.(Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. J Ethnopharmacol. 2002;81:105-109. 56. Sedighi M, Nazari A, Faghihi M, Rafieian‐Kopaei M, Karimi A, Moghimian M, et al. Protective effects of cinnamon bark extract against ischemia–reperfusion injury and arrhythmias in rat. Phytotherapy Res. 2018;32:1983-1991. 57. Akilen R, Pimlott Z, Tsiami A, Robinson N. Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes. Nutrition. 2013;29:1192-6. 58. Arase Y, Ikeda K, Murashima N, Chayama K, Tsubota A, Koida I, et al. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer. 1997;79:1494-1500. 59. Maarsingh H, Leusink J, Bos IST, Zaagsma J, Meurs H. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respiratory Res. 2006;7:1-7. 60. Morello S, Vellecco V, Alfieri A, Mascolo N, Cicala C. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life Sci. 2006;78:825-830. 61. Khoshnam SE. The effect of hydro-alcoholic extract of Glycyrrhiza glabra on the cardiovascular system of male rats with normal blood pressure and its interaction with cholinergic and adrenergic systems. Physiol Pharmacol. 2013. 62. Schulz V, Hänsel R, Tyler VE. Rational phytotherapy: a physician's guide to herbal medicine: Psychology Press. 2015;4:287-297 63. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm. 1999;56:125-138. 64. Rashid A, Khan HH. The mechanism of hypotensive effect of garlic extract. J Pak Med Assoc. 1985;35:357-362. 65. Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Medica. 1992;58:1-7. 66. Ebrahimiyan H, Bahaoddini A, Mohammadi J, Mohammadiyan M. The effect of hydroalcoholic extract of Juglans regia L. leaf on blood pressure and its interaction with adrenergic system of male rats. Tehran Univ Med J. 2016;73:895-9. 67. H. MH. Encyclopedia of Medicinal Plant of Iran. 5 ed. I. slamic Culture Press. 2004;4:220-222. 68. Antman EM. ST-segment elevation myocardial infarction: Pathology, pathophysiology, and clinical fetures. Braunwald's heart disease: A textbook of Cardiovasc Med. 2011;2. 69. Perrinjaquet‐Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytothera Res. 2008;22:1239-1242. 70. Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, et al. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20:392-397. 71. Saravanakumar M, Raja B. Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats. Eur J Pharmacol. 2011;671:87-94. 72. Sainz J, Wangensteen R, Gómez IR, Moreno JM, Chamorro V, Osuna A, et al. Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition. Am J Hypertens. 2005;18:871-877. 73. Fatehi M, Saleh TM, Fatehi-Hassanabad Z, Farrokhfal K, Jafarzadeh M, Davodi S. A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol. 2005;102:46-52. 74. Sumner MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, Marlin R, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol. 2005;96:810-814. 75. Seyam S. Study of situation of elderly residents in Guilan elderly nursing home. J Guilan Uni Med Sci. 2001;10:119-26. 76. Valadi A, Nasri S, Abbasi N, Amin GR. Antinociceptive and anti-inflammatory effects of hydroalchoholic extract of Anethum graveolens L. seed. J Med Plants. 2010;9. 77. Karimi E. Alzheimer's: Phytotherapy and the most important herbs in the treatment of Alzheimer's. Plant Biotechnol Persa. 2020;2:61-62. 78. Moayeri A, Azimi M, Karimi E, Aidy A, Abbasi N. Attenuation of morphine withdrawal syndrome by prosopis farcta extract and its bioactive component luteolin in comparison with clonidine in rats. Med Sci Moint Basic Res. 2018;24:151. 79. Eftekhari Z. Antimicrobial properties of medicinal plants; The new therapeutic aspect of Valeriana officinalis. Plant Biotechnol Persa. 2020;2:59-60. 80. Abbasi N, Aidy A, Shafiei M. Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iran J Med Sci. 2016;41:118. 81. Bahmani M, Taherikalani M, Khaksarian M, Rafieian-Kopaei M, Ashrafi B, Nazer M, et al. The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci OA. 2019;5:FSO371. 82. Abassi N, Ghaneialvar H, Shahsavari S. Natural remedies effective on stomachache in traditional medicine. Plant Biotechnol Persa. 2020;2:42-47. 83. Zangeneh MM, Ghaneialvar H, Akbaribazm M, Ghanimatdan M, Abbasi N, Goorani S, et al. Novel synthesis of Falcaria vulgaris leaf extract conjugated copper nanoparticles with potent cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing activities under in vitro and in vivo condition. J Jphotobiol. 2019;197:111556. 84. F. Magbool F, Ibrahim Elnima E, M. E S, I. Hamedelniel E, Mahmoud Gamil A, E. Adam M et al. Formulation, design, development and evaluation of QUERCUS Infectoria galls extract oral gels. Plant Biotechnol Persa. 2020;2:1-13. 85. Mahdavi B, Saneei S, Qorbani M, Zhaleh M, Zangeneh A, Zangeneh MM, et al. Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions. Appl Organometal Chem. 2019;33:e51.
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