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بررسی فیتوشیمیایی عصاره کلروفرمی ساقه Ferula ovina Boiss. | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 3، دوره 36، شماره 4 - شماره پیاپی 102، مهر و آبان 1399، صفحه 542-551 اصل مقاله (424.34 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2020.128427.2671 | ||
| نویسندگان | ||
| صبا قاسمی* 1؛ زهره حبیبی2؛ فاطمه رضا علیزاده روشن3 | ||
| 1استادیار، گروه شیمی، واحد ایلام، دانشگاه آزاد اسلامی، ایلام، ایران | ||
| 2دانشیار، گروه شیمی، دانشکده علوم، دانشگاه شهید بهشتی، تهران، ایران | ||
| 3دانشجوی کارشناسی ارشد رشته شیمی، دانشکده علوم، دانشگاه شهید بهشتی، تهران، ایران | ||
| چکیده | ||
| شناسه دیجیتال (DOR): 98.1000/1735-0905.1399.36.542.102.4.1576.46 در این تحقیق، بررسی عصاره کلروفرمی ساقه گیاه Ferula ovina Boiss.از خانواده چتریان بررسی شد. این گونه گیاهی در فصل گلدهی از استان تهران- دماوندجمعآوری شد.پس از خالصسازی عصاره با استفاده از کروماتوگرافی ستونی بر روی سیلیکاژل با گرادیان حلال n- هگزان - اتیلاستات 12 جزء بدست آمد. در نتیجه خالصسازی بیشتر این فرکشنها، چهار مشتق استری مونوترپنوئیدی به نامهای شیمگین (1)، (S1،R2،S4)-1،7،7-تریمتیل بیسیکلو [2.2.1] هپتان-2-ایل 4-متوکسی بنزوآت (2)، (S1،R2،S4)-1،7،7-تریمتیل بیسیکلو [2.2.1] هپتان-2-ایل 4-هیدروکسی-3-متوکسی بنزوآت (3) و استیلوزین (4) جداسازی و شناسایی شد. البته تاکنون هیچگونه گزارشی مبنی بر جداسازی ساختار ترکیب شماره 2 یافت نشده است. ساختار ترکیبها توسط روشهای طیفسنجی تعیین شد. در نهایت از طریق مقایسه ویژگیهای فیزیکیشامل نقطهذوب و چرخش نوریو دادههای طیفی آنها با آنچه که در منابع علمی معتبر گزارش شده است تأیید گردید. | ||
| کلیدواژهها | ||
| فیتوشیمی؛ Ferula ovina Boiss؛ عصاره؛ مونوترپنوئید؛ شیمگین؛ استیلوزین | ||
| عنوان مقاله [English] | ||
| Phytochemical study on the chloroform extract of Ferula ovina Boiss. stems | ||
| نویسندگان [English] | ||
| S. Ghasemi1؛ Z. Habibi2؛ F. Rezaalizadeh Rooshan3 | ||
| 1Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran | ||
| 2Department of Chemistry, Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran | ||
| 3M.Sc. student, Department of Chemistry, Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran | ||
| چکیده [English] | ||
| In this study, the chloroform extract of Ferula ovina (fam. Apiaceae) stems was investigated. The plants were collected at the flowering stage from Tehran province (Damavand), Iran. The extract was purified using column chromatography on silica gel with a solvent gradient of n-hexane-ethyl acetate and yielded 12 fractions. Further purification of the fractions resulted in the isolation and identification of four monoterpenoid ester derivatives named tschimgine (1), (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-methoxy benzoate (2), (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxy-3-methoxy benzoate (3) and stylosin (4). So far, no report has been found on the isolation and structure identification of the compound No.2. The structure of the compounds was determined by spectroscopic analysis andfinally confirmed by comparison of their spectral data, melting points, and optical rotations with those described in the literature. | ||
| کلیدواژهها [English] | ||
| Phytochemistry, Ferula ovina Boiss, extraction, monoterpenoid, tschimgine, stylosin | ||
| مراجع | ||
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- AbdEl-Razek, M.H., Ohta, S., Ahmed, A.A. and Hirata, T., 2001. Monoterpene coumarins from Ferula ferulago. Phytochemistry, 57(8): 1201-1203. - Afifi, F.U. and Abu-Irmaileh, B., 2000. Herbal medicine in Jordan with special emphasis on less commonly used medicinal herbs. Journal of Ethnopharmacology, 72: 101-110. - Bagirov, V.Y., Sheichenko, V.I., Aliev, G.V. and Pimenov, M.G., 1980. Esters from Ferula stylosa. Chemistry of Natural Compounds, 17: 562-563. - Boghrati, Z. and Iranshahi, M., 2019. Ferula species: A rich source of antimicrobial compounds. Journal of Herbal Medicine, 16: 100244. - Boulos, L., 1983. Medicinal Plants of North Africa, Reference Publications, Inc., Algonac, Michigan, 286p. - Eshbakova, K.A. and Saidkhodzhaev, A.I., 2003. Esters from Ferula samarcandica. Chemistry of Natural Compounds, 39: 221-222. - Ghannadi, A., Sajjadi, S.E. and Beigihasan, A., 2002. Composition of the essential oil of Ferula ovina (Boiss.) Boiss. from Iran. Daru Journal of Pharmaceutical Sciences, 10: 165-167. - Halberstein, R.A., 2005. Medicinal plants: historical and cross-cultural usage patterns. Annals of Epidemiology, 15: 686-699. - Ibraheim, Z.Z., Abdel-Mageed, W., Dai, H., Guo, H., Zhang, L. and Jaspars, M., 2012. Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss. Phytotherapy Research, 26: 579-586. - Iranshahi, M., Arfa, P., Ramezani, M., Jaafari, M.R., Sadeghian, H., Bassarello, C., Piacente, S. and Pizza, C., 2007. Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes. Phytochemistry, 68: 554-561. - Iranshahi, M., Famili, A., Bassarello, C., Piacente, S. and Pizza, C., 2010a. Purification and structure elucidation of compounds from the roots of Ferula ovina Boiss. Journal of Medicinal Plants, 4: 72-80. - Iranshahi, M., Kalategi, F., Sahebkar, A., Sardashti, A. and Schneider, B., 2010b. New sesquiterpene coumarins from the roots of Ferula flabelliloba. Pharmaceutical Biology, 48: 217-220. - Iranshahi, M., Mojarab, M., Sadeghian, H., Hanafi-Bojd, M.Y. and Schneider, B., 2008. Polar secondary metabolites of Ferula persica roots. Phytochemistry, 69: 473-478. - Iranshahi, M., Farhadi, F., Paknejad, B., Zareian, P., Iranshahi, M., Karami, M. and Abtahi, S.R., 2019. Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines. Avicenna Journal of Phytomedicine, 5: 446-453. - Jabrane, A., Ben Jannet, H., Mighri, Z., Mirjolet, J.F., Duchamp, O., Harzallah-Skhiri, F. and Lacaille-Dubois, M.A., 2010. Two New Sesquiterpene Derivatives from the Tunisian Endemic Ferula tunetana POM. Chemistry Biodiversity, 7: 392-399. - Kadyrov, A.S. and Nikonov, G.K., 1972. The structures of chimganin and chimgin. Chemistry of Natural Compounds, 8: 53-56. - Kahraman, C., Topcu, G., Bedir, E., Tatli, I.I., Ekizoglu, M. and Akdemir, Z.S., 2019. Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts. Saudi Pharmaceutical Journal, 27: 525-531. - Karimi, G., Iranshahi, M., Hosseinalizadeh, F., Riahi, B. and Sahebkar, A., 2010. Screening of acetylcholinesterase inhibitory activity of terpenoid and coumarin derivatives from the genus Ferula. Pharmacology online, 1: 566-574. - Mohammadhosseini, M., Venditti, A., Sarker, S.D., Nahar, L. and Akbarzadeh, A., 2019. The genus Ferula: Ethnobotany, phytochemistry and bioactivities-A review. Industrial Crops and Products, 129: 350-394. - Mortazaienezhad, F. and Sadeghian, M.M., 2006. Investigation of compounds from galbanum (Ferula gummosa) Boiss. Asian Journal of Plant Sciences, 5: 905-906. - Mozaffarian, V., 1996. A Dictionary of Iranian Plant Names. Tehran: Farhang-e Moaser, 228p. - Oughlissi-Dehak, K., Lawton, P., Michalet, S., Bayet, C., Darbour, N., Hadj-Mahammed, M., Badjah-Hadj-Ahmed, Y.A., Dijoux-Franca, M.G. and Guilet, D., 2008. Sesquiterpenes from aerial parts of Ferula vesceritensis. Phytochemistry, 69: 1933-1938. - Sayed-Ahmad, B., Talou, T., Saad, Z., Hijazi, A. and Merah, O., 2017. The Apiaceae: ethnomedicinal family as source for industrial uses. Industrial Crops and Products, 109: 661-671. - Soltani, S., Amin, G.R., Salehi-Sourmaghi, M.H., Schneider, B., Lorenz, S. and Iranshahi, M., 2018. Sulfur-containing compounds from the roots of Ferula latisecta and their cytotoxic activities. Fitoterapia, 124: 108-112. - Tamemoto, V., Takaishi, Y., Chen, B., Kawazoe, K., Shibata, H., Higuti, T., Honda, G., Ito, M., Takeda, Y., Kodzhimatov, K.O. and Ashurmetov, O., 2001. Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica. Phytochemistry, - Yousefi, M., Mohammadi, M., Habibi, Z. and Shafiee, A., 2010. New polysulfanes from aerial parts of Ferula behboudiana Rech. f. & Esfand. Natural Product Research, 24: 1352-1357. - Zanoli, P., Rivasi, M., Zavatti, M., Brusiani, F., Vezzalini, F. and Baraldi, M., 2005. Activity of single components of Ferula hermonis on male rat sexual behavior. International Journal of Impotence Research, 17: 513-518. - Zargari, A., 1996. Medicinal Plants (Vol 4). Tehran University Publication, Tehran, 948p. - Zargari, A., 1997. Medicinal Plants (Vol 1). Tehran University Publication, Tehran, 976p. - Zhi-da, M., Qi-fi, M., Mizuno, M., Tanaka, T., Iinuma, M., 1987. Polysulfanes in the volatile oil of Ferula species. Planta Medica, 53: 300-302. - Zhou, P., Takaishi, Y., Duan, H., Chen, B., Honda, G., Itoh, M., Takeda, Y., Kodzhimatov, K.O. and Lee, H., 2000. Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release. Phytochemistry, 53: 689-697. | ||
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