News

a.z
Javadian, N., Veshkini, A., Jahandideh, A., Akbarzadeh, A., Asghari, A. (2021). Ultrasonographic evaluation of Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of femurbone defect in rabbits. , 34(3), 114-120. doi: 10.22092/vj.2020.341723.1686
N. Javadian; A. Veshkini; A. Jahandideh; A. Akbarzadeh; A. Asghari. "Ultrasonographic evaluation of Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of femurbone defect in rabbits". , 34, 3, 2021, 114-120. doi: 10.22092/vj.2020.341723.1686
Javadian, N., Veshkini, A., Jahandideh, A., Akbarzadeh, A., Asghari, A. (2021). 'Ultrasonographic evaluation of Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of femurbone defect in rabbits', , 34(3), pp. 114-120. doi: 10.22092/vj.2020.341723.1686
Javadian, N., Veshkini, A., Jahandideh, A., Akbarzadeh, A., Asghari, A. Ultrasonographic evaluation of Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of femurbone defect in rabbits. , 2021; 34(3): 114-120. doi: 10.22092/vj.2020.341723.1686

Ultrasonographic evaluation of Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of femurbone defect in rabbits

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 15, Volume 34, Issue 3, October 2021, Pages 114-120    PDF (492.77 K)
Document Type: Full Research Paper
DOI: 10.22092/vj.2020.341723.1686
Authors
N. Javadian1; A. Veshkini* 2; A. Jahandideh3; A. Akbarzadeh4; A. Asghari3
1Department of veterinary medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Radiology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Surgery , Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Department of Medical Nanotechnology, School of Advanced Medical Sciences, Stem Cell Research Center, Stem Cells and Regenerative Medicine Institute, Tabriz University of Medical Sciences
Abstract
Nowadays, nanocomposite biomaterials are used to reduce bone repair complications because of tissue adaptation, good resistance and lack of cytotoxicity.The current research was done to study the effects of zeolite/collagen nanocomposite bone scaffold on healing process of experimental defect in rabbit femur using ultrasonographic examination. Twenty-eight mature male New Zealand white rabbits after injecting general anesthesia and topical preparation underwent surgery then with a low speed orthopedic drill, a 5-6 mm defect created in the proximal femur.they classified into 4 groups of 7 animals each. In the first group the defect was made and with no treatment the defect was closed. In the second group the nanohydroxyapatite was implanted into the defect. In the third group the nanocomposite of zeolite/collagen was implanted and in the 4th group the defect was filled using autograft.. Finally they were closed with sutures & ultrasonographic examination was done on days 0, 15, 30, 45 and 60 postoperatively. No angiogenesis was observed on day 0 and the highest angiogenesis rate on day 7 was related to the zeolite/collagen nanocomposite group. The highest angiogenesis rate on day 15 is related to nano-hydroxyapatite & zeolite/collagen nanocomposite and on day 30 is related to the zeolite/collagen nanocomposite. The highest angiogenesis rate on day 45 is related to the zeolite/collagen nanocomposite and on day 60 is related to the zeolite/collagen nanocomposite group that the efficacy of the collagen zeolite nanocomposite group over other groups was demonstrated in our study. Amounts of bone filling and angiogenesis in rabbits treated with zeolite/collagen nanocomposite were higher than other tested groups. Zeolite/collagen nanocomposite scaffold bear a crucial capability in the reconstruction of bone defects and could be used as scaffold in bone fractures.
Keywords
Ultrasonography; Zeolite/collagen nanocomposite; Bone scaffolds; Rabbit
References

1- Abbasnia, P., M. M. Dehghan, M. Molazem, S. M. Nassiri, A. R. Vajhi, D. Sharifi, et al. 2014. Comparison of diagnostic accuracy of ultrasonography and radiology in radial critical-sized defects healing process in rabbit. Journal of Veterinary Research 69: 103-110.
2. Faraji, D., A. Jahandideh, A. Asghari, A. Akbarzadeh and S. Hesaraki. 2017. Effect of Zeolite and Zeolite/Collagen Nanocomposite Scaffolds on Healing of Segmental Femur Bone Defect in Rabbits. Iranian Journal of Veterinary Surgery 12: 63-70.
3. Faraji, D., A. Jahandideh, A. Asghari, A. Akbarzadeh and S. Hesaraki. 2019. Evaluation of Influence of Zeolite/Collagen Nanocomposite (ZC) and Hydroxyapatite (HA) on Bone Healing: A Study on Rabbits. Archives of Razi Institute. 74: 395-403.
4. Jayakumar, R., D. Menon, M. Koyakutty, S. V. Nair and H. Tamura. 2010. Biomedical applications of chitin and chitosan based nanomaterials—A short review. Journal of Carbohydrate Polymers 82: 227-232.
5. Liu, S., J. Wu, X. Liu, D. Chen, G. L. Bowlin, L. Cao, J. Lu, F. Li, X. Mo and C. Fan. 2015. Osteochondral regeneration using an oriented nanofiber yarn-collagen type I/hyaluronate hybrid/TCP biphasic scaffold. Journal of Biomedical Materials Research Part A 103: 581-592.
6. Marjani M, Asgarian A, Veshkini A, Tavasoli A. 2012. Evaluation of biocompatibility implantation of the Persian Gulf’s coral in femoral defect of rabbit. Journal of Qazvin University Medicine Sciense 11: 8-14 (in Farsi)
7. Mohseni, M., A. Jahandideh, G. Abedi, A. Akbarzadeh and S. Hesaraki. 2018. Assessment of tricalcium phosphate/collagen (TCP/collagene) nanocomposite scaffold compared with hydroxyapatite (HA) on healing of segmental femur bone defect in rabbits. Nanomedicine Biotechnology 46: 242-249.
8. Mozafari, S. Kargozar, S., J. Hashemian, P. Brouki Milan, et al. 2018. Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue. Journal of Biomedical Materials Research 106: 61-72.
9. Murawski, M., T. Schwarz, V. Erak, J. Sohal, B. Ahmadi, R. T. Kridli and P. M. Bartlewski. 2020. Lack of Efect of Short-term Lupin Grain Feeding on Ovulation Rate in Non-prolific Polish Mountain Ewes during the Breeding Season: Ultrasonographic and Endoscopic Assessment of Ovarian Activity. Archives of Razi Institute. 75: 481-490.
10. Rahimzadeh, R., A. Veshkini, D. Sharifi and S. Hesaraki. 2012. Value of color Doppler ultrasonography and radiography for the assessment of the cancellous bone scaffold coated with nano-hydroxyapatite in repair of radial bone in rabbit. Acta Cirurgica Brasileira 27: 148-154.
11. Schumacher, M., F. Uhl, R. Detsch, U. Deisinger and G. Ziegler. 2010. Static and dynamic cultivation of bone marrow stromal cells on biphasic calcium phosphate scaffolds derived from an indirect rapid prototyping technique. Journal of Materials Science: Materials in Medicine 21(11):3039-48.
12. Yang, W., F. Yang, Y. Wang, S. K. Both and J. A. Jansen. 2013. In vivo bone generation via the endochondral pathway on three-dimensional electrospun fibers. Acta Biomaterialia 9: 4505-4512.
13. Yun, H.-S., J.-W. Park, S.-H. Kim, Y.-J. Kim and J.-H. Jang. 2011. Effect of the pore structure of bioactive glass balls on biocompatibility in vitro and in vivo. Acta biomaterialia 7: 2651-2660.
14. Zhou, G., S. Liu, Y. Ma, W. Xu, W. Meng, X. Lin, et al. 2017. Innovative biodegradable poly (L-lactide)/collagen/hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation. International Journal of Nanomedicine 12: 7577-7588.

Statistics
Article View: 783
PDF Download: 703


counter
Journal management system. designed by sinaweb