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Enhancement of Productive Performance, Bone Physical Characteristics, and Mineralization of Laying Hens during the Post-Peak Period by Genistein | ||
| Archives of Razi Institute | ||
| مقاله 19، دوره 76، شماره 2، شهریور 2021، صفحه 359-369 اصل مقاله (444.03 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2020.342143.1454 | ||
| نویسندگان | ||
| T Saberifar* 1؛ F Samadi1؛ B Dastar1؛ S Hasani1؛ M Kazemifard2؛ F Ganji3 | ||
| 1Faculty of Animal Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran | ||
| 2Department of Animal Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran | ||
| 3Department of Biology, Faculty of Sciences, Golestan University, Gorgan, Iran | ||
| چکیده | ||
| Genistein (GEN), a soybean isoflavone, is structurally and functionally similar to endogenous estrogen; therefore, it has the potential to enhance estradiol properties. This study aimed to evaluate the effects of GEN on the reproductive performance and bone status of laying hens. In total, 80 Hy-line W-36 (40 weeks old, the late stage of egg production cycle) with an initial body weight of 1,230±15.8 g (Mean±S.E.M), similar egg production, and egg weight were randomly assigned into two groups with 10 replicates and 4 birds in each replicate (40 laying hens per group). Laying hen diets had 0 (control) and 20 mg/kg GEN (white powder, Sichuan Guanghan co. Ltd., purity of 98.5%) for 6 weeks (41 to 46). At the end of the experiment, 20 hens (one hen from each replicate) were slaughtered, and the samples of bone and shell gland (approximately 50 mg) were surgically taken immediately after slaughter for Real-time PCR. The results indicated that dietary GEN increased egg production, feed intake, and egg mass; however, it decreased egg weight (p <0.05). Furthermore, the feed conversion ratio was greater in birds received GEN, compared to those in the control group (p <0.05). GEN enhanced egg quality indices included eggshell strength, thickness, and percentage (p <0.05). Mechanical properties of the tibia, such as weight, length, and breaking strength were also increased by GEN (p <0.05). Moreover, dietary GEN increased the calcium content of the tibia (p <0.05). The mRNA expression of Calbindin-D28k (CaBP-D28k) and transient receptor potential vanilloid channel type 6 (TRPV6) upregulated in eggshell glands of hens treated with GEN paralleled to the controls (p <0.05). In conclusion, the findings of the present study showed that GEN had the potential to improve the bone physical characteristics, mineralization, and the productive performance of Hy-line W-36 laying hens in their post-peak period. | ||
| کلیدواژه‌ها | ||
| Bone؛ CaBP-D28k؛ Genistein؛ Productive performance؛ TRPV6 | ||
| عنوان مقاله [English] | ||
| تاثیر جنستئین بر عملکرد تولیدی و شاخص های مکانیکی استخوان مرغان تخمگذار پس از دوره پیک تولید | ||
| چکیده [English] | ||
| جنیستئین (GEN)، ایزوفلاوون سویا و از نظر ساختاری و عملکردی مشابه استروژن درون زا است. بنابراین، این پتانسیل را دارد که خواص استرادیول را تقویت کند. این پژوهش به منظور بررسی آثار GEN بر عملکرد تولید مثلی و شاخص‌های مکانیکی استخوان مرغان تخمگذار پس از دوره پیک تولید طراحی شد. شمار هشتاد قطعه مرغ تخمگذار (WK Hy-line W-36) با وزن اولیه 8/15±1230 گرم به صورت تصادفی به دو گروه (گروه کنترل تغذیه جیره پایه و گروه دوم جیره پایه بعلاوه 20 میلی گرم در کیلوگرم GEN) با 10 تکرار و 4 پرنده در هر تکرار تقسیم شدند و به مدت شش هفته (هفته 41 تا 46) تغذیه شدند. در پایان آزمایش 20 مرغ (یک مرغ از هر تکرار) کشتار و نمونه‌های استخوان و غده پوسته برای بررسی بیان ژن مورد استفاده قرار گرفتند. نتایج نشان داد که مکمل GEN باعث افزایش تولید تخم مرغ، افزایش مصرف خوراک، افزایش توده تخم مرغ و کاهش وزن تخم مرغ شد (05/0>P). ضریب تبدیل خوراک در پرندگان دریافت کننده GEN نسبت به گروه کنترل بهتر بود (05/0>P). مکمل GEN باعث افزایش شاخص‌های کیفیت تخم مرغ از جمله مقاومت پوسته تخم مرغ، ضخامت پوسته تخم مرغ و درصد پوسته تخم مرغ شد (05/0>P). خواص مکانیکی استخوان درشت نی مانند وزن ، طول و استحکام شکست توسط مکمل GEN افزایش یافت (05/0>P). مکمل GENمیزان کلسیم استخوان درشت نی را افزایش داد. (05/0>P). بیان mRNA مربوط به ژن‌های پروتئین متصل شونده به کلسیم(CaBP-D28k) و گیرنده گذرا بالقوه کانال وانیلوئید نوع 6 (TRPV6) در غدد پوسته تخم مرغ مرغ-های تغذیه شده با GEN در مقایسه با کنترل افزایش یافت (05/0>P). یافته های پژوهش حاضر نشان داد که مکمل GEN پتانسیل بهبود وضعیت استخوان و عملکرد تولیدی مرغ تخمگذار را در دوره پس از پیک تولید دارد | ||
| کلیدواژه‌ها [English] | ||
| استخوان, جنئستین, عملکرد تولیدمثلی, CaBP-D28k, TRPV6 | ||
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