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Correlation of C-Reactive Protein and Serum Iron Levels with Syntax Score | ||
| Archives of Razi Institute | ||
| مقاله 13، دوره 75، شماره 3، آذر 2020، صفحه 413-418 اصل مقاله (114.38 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2020.128122.1404 | ||
| نویسنده | ||
| B. Ozdemir* | ||
| Department of Cardiology Faculty of Medicine, Nigde Omer Halisdemir University, Campus, 51240, Nigde, Turkey | ||
| چکیده | ||
| Cardiovascular disease is one of the most common causes of morbidity and mortality in the world. Atherosclerosis is an inflammatory process, and serum C-reactive protein (CRP) is an acute-phase protein rising in response to inflammation. Serum iron (Fe) is one of the essential metals for the human body. Inflammation and infection are characterized by changes in Fe metabolism. Since atherosclerosis is an inflammatory process, changes in CRP and serum Fe levels are expected. However, the distribution of the disease in the coronary arteries is important for mortality and morbidity. The distribution of the disease can be determined by the syntax score. This study included 407 patients with a mean age of 56.4±10.7 years. The majority of the patients were male (51.4%). In this study, 53 and 354 patients had critical and no critical lesions, respectively. According to the baseline coronary angiograms, the syntax score was calculated in all patients. The laboratory variables, including hemoglobin levels, blood glucose, creatinine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, Fe, and CRP were also evaluated in this study. Regarding the laboratory parameters of all groups, the mean CRP levels, Fe levels, and syntax score were estimated at 0.75±1.8 mg/dl, 80.4±27.5 mg/dl, and 1.5±4.8, respectively. Furthermore, a high syntax score correlated with Fe and CRP levels. Based on the findings of the present study, elevated serum Fe and CRP concentrations were associated with increased syntax score and atherosclerosis severity. | ||
| کلیدواژهها | ||
| Atherosclerosis؛ C-reactive protein؛ Serum iron؛ Syntax score | ||
| عنوان مقاله [English] | ||
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| چکیده [English] | ||
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| کلیدواژهها [English] | ||
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|
Ascherio, A., Willett, W.C., Rimm, E.B., Giovannucci, E.L., Stampfer, M.J., 1994. Dietary iron intake and risk of coronary disease among men. Circulation 89, 969-974.
Bisoendial, R.J., Boekholdt, S.M., Vergeer, M., Stroes, E.S., Kastelein, J.J., 2010. C-reactive protein is a mediator of cardiovascular disease. Eur Heart J 31, 2087-2091.
Devaraj, S., Singh, U., Jialal, I., 2009. The evolving role of C-reactive protein in atherothrombosis. Clin Chem 55, 229-238.
Drakopoulou, M., Toutouzas, K., Stefanadi, E., Tsiamis, E., Tousoulis, D., Stefanadis, C., 2009. Association of inflammatory markers with angiographic severity and extent of coronary artery disease. Atherosclerosis 206, 335-339.
Emerging Risk Factors, C., Kaptoge, S., Di Angelantonio, E., Pennells, L., Wood, A.M., White, I.R., et al., 2012. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 367, 1310-1320.
Garg, S., Sarno, G., Garcia-Garcia, H.M., Girasis, C., Wykrzykowska, J., Dawkins, K.D., et al., 2010. A new tool for the risk stratification of patients with complex coronary artery disease: the Clinical SYNTAX Score. Circ Cardiovasc Interv 3, 317-326.
Gozzelino, R., Arosio, P., 2016. Iron Homeostasis in Health and Disease. Int J Mol Sci 17, 130-143.
Guan, H., Wang, P., Hui, R., Edin, M.L., Zeldin, D.C., Wang, D.W., 2009. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Clin Chem 55, 274-284.
Jialal, I., Devaraj, S., Venugopal, S.K., 2004. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 44, 6-11.
Koenig, W., 2013. High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy. Int J Cardiol 168, 5126-5134.
Magnusson, M.K., Sigfusson, N., Sigvaldason, H., Johannesson, G.M., Magnusson, S., Thorgeirsson, G., 1994. Low iron-binding capacity as a risk factor for myocardial infarction. Circulation 89, 102-108.
Meyers, D.G., 1996. The iron hypothesis--does iron cause atherosclerosis? Clin Cardiol 19, 925-929.
Neven, E., De Schutter, T.M., Behets, G.J., Gupta, A., D'Haese, P.C., 2011. Iron and vascular calcification. Is there a link?Nephrol Dial Transplant 26, 1137-1145.
Pan, H.C., Sheu, W.H., Lee, W.J., Lee, W.L., Liao, Y.C., Wang, K.Y., et al., 2015. Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD study). Clin Chim Acta 445, 93-100.
Pepys, M.B., Rowe, I.F., Baltz, M.L., 1985. C-reactive protein: binding to lipids and lipoproteins. Int J Clin Exp Pathol 27, 83-111.
Pilote, L., Joseph, L., Bélisle, P., Robinson, K., Van Lente, F., Tager, I.B., 2000. Iron stores and coronary artery disease: A clinical application of a method to incorporate measurement error of the exposure in a logistic regression model. J Clin Epidemiol 53, 809-816.
Reunanen, A., Knekt, P., Marniemi, J., Mäki, J., Maatela, J., Aromaa, A., 1996. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Eur J Clin Nutr 50, 431-437.
Salonen, J.T., Nyyssonen, K., Korpela, H., Tuomilehto, J., Seppanen, R., Salonen, R., 1992. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86, 803-811.
Sempos, C.T., Looker, A.C., Gillum, R.F., 1996. Iron and heart disease: the epidemiologic data. Nutr Rev 54, 73-84.
Sempos, C.T., Looker, A.C., Gillum, R.F., McGee, D.L., Vuong, C.V., Johnson, C.L., 2000. Serum Ferritin and Death from all Causes and Cardiovascular Disease: The NHANES II Mortality Study. Ann Epidemiol 10, 441-448.
Serruys, P.W., Morice, M.C., Kappetein, A.P., Colombo, A., Holmes, D.R., Mack, M.J., et al., 2009a. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 360, 961-972.
Serruys, P.W., Onuma, Y., Garg, S., Sarno, G., van den Brand, M., Kappetein, A.P., et al., 2009b. Assessment of the SYNTAX score in the Syntax study. EuroIntervention 5, 50-56.
Steinberg, D., 1986. Modification of LDL that increases it's atherogenicity. Am J Med 320, 1182-1184.
Sullivan, J., 1981. Iron and the sex difference in heart disease risk. Lancet 317, 1293-1294.
Valgimigli, M., Serruys, P.W., Tsuchida, K., Vaina, S., Morel, M.A., van den Brand, M.J., et al., 2007. Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Am J Cardiol 99, 1072-1081.
van Gaal, W.J., Ponnuthurai, F.A., Selvanayagam, J., Testa, L., Porto, I., Neubauer, S., et al., 2009. The Syntax score predicts peri-procedural myocardial necrosis during percutaneous coronary intervention. Int J Cardiol 135, 60-65.
Verma, S., Wang, C.H., Li, S.H., Dumont, A.S., Fedak, P.W., Badiwala, M.V., et al., 2002. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 106, 913-919.
Zethelius, B., Berglund, L., Sundstrom, J., Ingelsson, E., Basu, S., Larsson, A., et al., 2008. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 358, 2107-2116. | ||
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