| تعداد نشریات | 282 |
| تعداد نشریات سازمان | 80 |
| تعداد شمارهها | 3,219 |
| تعداد مقالات | 35,690 |
| تعداد مشاهده مقاله | 53,561,419 |
| تعداد دریافت فایل اصل مقاله | 92,841,656 |
Bioactivity of EtOH and MeOH Extracts of Basidiomycetes Mushroom (Stereum hirsutum) on Atherosclerosis | ||
| Archives of Razi Institute | ||
| مقاله 12، دوره 76، شماره 1، خرداد 2021، صفحه 87-94 اصل مقاله (219.82 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.126283.1340 | ||
| نویسندگان | ||
| M Sevindik1؛ B Ozdemir2؛ C Bal3؛ Z Selamoglu* 4 | ||
| 1Department of Food Processing, Bahçe Vocational School, Osmaniye Korkut Ata University, Osmaniye, Turkey | ||
| 2Department of Cardiology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey | ||
| 3Oguzeli Vocational School, Gaziantep University, Gaziantep, Turkey | ||
| 4Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey | ||
| چکیده | ||
| Mushrooms are cosmopolitan organisms living on different substrates and have different pharmacological properties, such as antioxidant, antimicrobial, and anti-inflammatory effects thanks to many bioactive compounds. Edible and medicinal higher fungi have been used by humankind for millennia. They are collected and used directly not only for their nutritional values as a main source of food or as a part of a regular diet but also for their medicinal purpose as a source of powerful new bioactive compounds. Antioxidative and anti-inflammatory functions and therefore lipid-lowering effects correlate with antiatherogenic effects. This study determined the total antioxidant capacity (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), 1-diphenyl-2-picrylhydrazyl (DPPH) activity, and antimicrobial activity of ethanolic and methanolic extracts of Stereum hirsutum (Willd.) Pers. Moreover, the effects on atherosclerosis are discussed according to the antioxidant activity of the mushroom. The TAS, TOS, and OSI values of S. hirsutum were determined using Rel Assay kits. According to the results, the TAS, TOS, and OSI values were determined at 5.289±0.113 mmol/L, 20.540±0.416 μmol/L, and 0.389±0.012. Furthermore, free radical scavenging activity was determined by the DPPH method. The ethanol (EtOH) extracts of S. hirsutum showed higher DPPH activity than methanol extracts. The EtOH extracts at a concentration of 2 mg/mL showed a DPPH inhibition of 45.84±0.81%. Antimicrobial activities were tested on 9 standard bacterial and fungal strains, including Staphylococcus aureus, S. aureus MRSA, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans, C. krusei,and C. glabrata using a modified agar dilution method. Extracts showed high activity against S. aureus, S. aureus MRSA, and A.baumannii. In conclusion, it was suggested that S. hirsutum can be used as a natural source related to the effects on atherosclerosis due to its antioxidant and antimicrobial activities. | ||
| کلیدواژهها | ||
| Antioxidant؛ Antimicrobial؛ Atherosclerosis؛ Mushroom؛ Stereum hirsutum | ||
| عنوان مقاله [English] | ||
| . | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Aqueveque, P., Cespedes, C.L., Becerra, J., Aranda, M., Sterner, O., 2017. Antifungal activities of secondary metabolites isolated from liquid fermentations of Stereum hirsutum (Sh134-11) against Botrytis cinerea (grey mould agent). Food Chem Toxicol 109, 1048-1054.
Asatiani, M.D., Elisashvili, V.I., Wasser, S.P., Reznick, A.Z., Nevo, E., 2007. Free-radical scavenging activity of submerged mycelium extracts from higher basidiomycetes mushrooms. Biosci Biotechnol Biochem 71, 3090-3092.
Bauer, A.W., Kirby, W.M., Sherris, J.C., Turck, M., 1966. Antibiotic susceptibility testing by astandardized single disk method. Am J Clin Pathol, 45, 493-96.
Bal, C., 2018. A Study on Antioxidant Properties of Gyrodon lividus. Eurasian J For Sci 6, 40-43.
Bal, C., 2019. Antioxidant and antimicrobial capacities of Ganoderma lucidum. J Bacteriol Mycol Open Access 7, 5-7.
Bal, C., Akgul, H., Sevindik, M., Akata, I., Yumrutas, O., 2017. Determination of the anti-oxidative activities of six mushrooms. Fresenius Envir Bull, 26(10), 6246-6252.
Bal, C., Sevindik, M., Akgul, H., Selamoglu, Z., 2019. Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma, 37(1), 1-5.
Balsano, C., Alisi, A., 2009. Antioxidant effects of natural bioactive compounds. Current pharmaceutical design. Curr Pharm Des 15, 3063-3073.
Bishop, K.S., Kao, C.H., Xu, Y., Glucina, M.P., Paterson, R.R., Ferguson, L.R., 2015. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 114, 56-65.
Calvo, A.M., Wilson, R.A., Bok, J.W., Keller, N.P., 2002. Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev 66, 447-459.
CLSI (The Clinical and Laboratory Standards Institute). 2012. Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard-Eighth Edition (M11-A8).
Erel, O., 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin biochem 37, 277-285.
Erel, O., 2005. A new automated colorimetric method for measuring total oxidant status. Clin biochem 38, 1103-1111.
EUCAST (European Committee on Antimicrobial Susceptibility Testing). 2014. Breakpoint tables Fungal isolate for interpretation of MICs. 2014; Version 7.0 EUCAST (European Committee on Antimicrobial Susceptibility Testing). 2015. Breakpoint tables for Bacteria interpretation of MICs and zone diameters 2015; Version 5.0
Gürgen, A., Yildiz, S., Kılıç, C., Can, Z., 2017. Protein contents and antioxidant properties of Pleurotus ostreatus cultivated on tea and espresso wastes. Int J Sec Metabol 4, 177-186.
Hindler, J., Hochstein, L., Howell, A., 1992. Preparation of routine media and reagents used in antimicrobial susceptibility testing. Part 1. McFarland standards, p. 5.19.1-5.19.6. In H. D. Isenberg (ed) Clinical microbiology procedures handbook, 1. American Society for Microbiology, Washington, D.C.
Kalač, P., 2009. Chemical composition and nutritional value of European species of wild growing mushrooms: A review. Food Chem 113, 9-16.
Krupodorova, T., Sevindik, M., 2020. Antioxidant potential and some mineral contents of wild edible mushroom Ramaria stricta. AgroLife Sci. J, 9, 186-191.
Li, H., Horke, S., Forstermann, U., 2013. Oxidative stress in vascular disease and its pharmacological prevention. Trends Pharmacol Sci 34, 313-319.
Liu, Z.N., Zheng, S.F., 1994. Structural correction of the fruiting body for Golden Ears. Edible Fungi 16, 12-13.
Matuschek, E., Brown, D.F., Kahlmeter, G., 2014. Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiolog laboratories. Clin Microbiol Infect, 20, 255-266
Nowacka, N., Nowak, R., Drozd, M., Olech, M., Los, R., Malm, A., 2015. Antibacterial, Antiradical Potential and Phenolic Compounds of Thirty-One Polish Mushrooms. PloS one 10, e0140355.
Prasad, S., Rathore, H., Sharma, S., As, Y., 2015. Medicinal Mushrooms as a Source of Novel Functional Food. Int J Food Sci Nutr Diet 4, 221-225.
Selamoglu, Z., Sevindik, M., Bal, C., Ozaltun, B., Sen, İ., Pasdaran, A., 2020. Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P.Kumm. Biointerface Res Appl Chem, 10(3), 5500-5506.
Sevindik, M., Akgul, H., Akata, I., Alli, H., Selamoglu, Z., 2017. Fomitopsis pinicola in healthful dietary approach and their therapeutic potentials. Acta Aliment 46, 46, 464.
Sevindik, M., Akgul, H., Bal, C., Selamoglu, Z., (2018). Phenolic contents, oxidant/antioxidant potential and heavy metal levels in Cyclocybe cylindracea. Int J Pharm Edu Res, 52(3), 437-441.
Sevindik, M., 2019. The novel biological tests on various extracts of Cerioporus varius. Fresen Environ Bull, 28(5), 3713-3717.
Sevindik, M., 2020. Antioxidant and antimicrobial capacity of Lactifluus rugatus and its antiproliferative activity on A549 cells. Indian J Tradit Knowl, 19(2), 423-427.
Shimada, K., Fujikawa, K., Yahara, K., Nakamura, T., 1992. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agr Food Chem 40, 945-948.
Su, P.W., Yang, C.H., Yang, J.F., Su, P.Y., Chuang, L.Y., 2015. Antibacterial Activities and Antibacterial Mechanism of Polygonum cuspidatum Extracts against Nosocomial Drug-Resistant Pathogens. Molecules 20, 11119-11130.
Torres, S., Cabrera-Pardo, J.R., Alonso, F., Bustos, E., Perez, C., Palfner, G., et al., 2016. Changes in secondary metabolites profiles and biological activity of the fresh fruiting bodies of Stereum hirsutum exposed to high-dose UV-B radiation. J Chil Chem Soc 61, 3224-3227.
Witztum, J.L., Steinberg, D., 2001. The Oxidative Modification Hypothesis of Atherosclerosis: Does It Hold for Humans? Trends Cardiovasc Med 11, 93-102.
Yadav, A., Kumari, R., Yadav, A., Mishra, J.P., Srivastava, D.S., Prabha, S., 2016. Antioxidants and its functions in human body - A Review. Res Env Life Sci 9, 1328-1331.
Young, I.S., Woodside, J.V., 2001. Antioxidants in health and disease. J Clin Path 54, 176-186. | ||
|
آمار تعداد مشاهده مقاله: 2,772 تعداد دریافت فایل اصل مقاله: 3,278 |
||
