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ارزیابی هماتولوژیک مصرف عصاره هیدروالکلی میوه بنه (Pistachia atlantica Desf.) در موشهای نر بزرگ سفید آزمایشگاهی نژاد ویستار | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 6، دوره 34، شماره 6 - شماره پیاپی 92، بهمن و اسفند 1397، صفحه 936-948 اصل مقاله (371 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2019.121631.2305 | ||
| نویسندگان | ||
| رضا آزادبخت1؛ محسن جعفریان دهکردی2؛ سکینه خنامانی فلاحتی پور* 3؛ عبداله قاسمی پیربلوطی4؛ سوده خنامانی فلاحتی پور5 | ||
| 1دانشجوی دکترا، دستیار تخصصی بیمارهای داخلی دامهای بزرگ، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران | ||
| 2استادیار، گروه علوم درمانگاهی، دانشکده دامپزشکی، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران | ||
| 3استادیار، مرکز تحقیقات فیزیولوژی-فارماکولوژی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران | ||
| 4دانشیار، مرکز تحقیقات گیاهان دارویی، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران | ||
| 5استادیار، مرکز تحقیقات سلامت پسته، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران | ||
| چکیده | ||
| بنه (Pistacia atlantica Desf.) از زیرگونههای پسته و از گیاهان دارویی بومی ایران است. بنه بهدلیل داشتن خواص متنوع در طب سنتی کاربرد دارد. این مطالعه بهمنظور بررسی اثرهای عصاره هیدروالکلی بنه بر پارامترهای خونی موش صحرایی طراحی و انجام شد. تعداد 18 سر موشصحرایی نر نژاد ویستار با وزن تقریبی 170 تا 240 گرم، به 3 گروه 6 تایی تقسیم شدند. تجویز خوراکی در گروه اول تا سوم بهترتیب با عصاره بنه mg/kg bw200، بنه mg/kg bw400 و آبمقطر (گروه شاهد) به مدت 30 روز از طریق گاواژ انجام شد. سپس نمونههای خون از قلب موشها گرفته و آزمایشهای هماتولوژی روی نمونهها انجام شد. دادههای حاصل با نرمافزار SPSS نسخه 21، آزمونهای آنالیز واریانس یکطرفه و توکی آنالیز شدند. تجویز غلظتهای مختلف عصاره هیدروالکلی بنه، تعداد گلبولهای قرمز (RBC)، تعداد گلبولهای سفید (WBC) و غلظت هموگلوبین (Hb) موشهای صحرایی را در گروههای آزمایش در مقایسه با گروه شاهد بهطور معنیداری بالا برد. بهعلاوه حجم متوسط گلبولهای قرمز خون (MCV) در گروه آزمایش دریافتکننده بنه با غلظت mg/kg bw200 در مقایسه با گروه کنترل بهطور معنیداری کاهش یافت؛ اما تأثیری بر سایر پارامترهای خونی نگذاشت (0.05>P). عصاره بنه تعداد گلبولهای قرمز و غلظت هموگلوبین را افزایش داد که میتواند احتمالاً بهدلیل افزایش در فرایند خونسازی باشد. همچنین افزایش جمعیت گلبولهای سفید خون بعد از تیمار با عصاره بنه، میتواند توانایی بدن را در برابر عوامل پاتوژن افزایش دهد. | ||
| کلیدواژهها | ||
| بنه (Pistacia atlantica Desf.)؛ طب سنتی؛ تجویز خوراکی؛ آزمایشهای هماتولوژی | ||
| عنوان مقاله [English] | ||
| Hematologic evaluation of the use of hydroalcoholic extract of baneh (Pistacia atlantica Desf.) fruit in wistar white male rats | ||
| نویسندگان [English] | ||
| R. Azadbakht1؛ M. Jafarian Dehkordi2؛ S. Khanamani Falahatipour3؛ A. Ghasemi Piirbalouti4؛ S. Khanamai Falahati-Pour5 | ||
| 1Ph.D. student, Resident of Large Animal Internal Medicine, Science and Research Branch, Azad Islamic University, Tehran, Iran | ||
| 2Department of Clinical Pathology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran | ||
| 3Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| 4The Center of Medicinal Plants Researches, Faculty of Agriculture, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran | ||
| 5Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| چکیده [English] | ||
| Baneh (Pistacia atlantica Desf.) is a subspecies of pistachio and a native medicinal plant to Iran. Due to its diverse properties, Baneh is being applied in traditional medicine. The present experimental study was designed to evaluate the effects of the hydroalcoholic extract of Baneh on the hematological parameters of rats. Eighteen male Wistar rats weighing 170-240 gr were divided into three six-member groups. Oral administration in groups 1 to 3 was performed by gavage with 200 mg/kg bw of the extract, 400 mg/kg bw of the extract and distilled water (control group) for 30 days, respectively. Then, blood samples were taken from the heart of rats and hematological tests were done on the samples. The obtained data were analyzed using SPSS software version 21, one-way ANOVA, and Tukey tests. Administration of different concentrations of hydroalcoholic extract significantly increased the number of red blood cells (RBC), white blood cells (WBC), and hemoglobin (Hb) concentration in test groups compared with the control group. In addition, the average volume of red blood cells (MCV) decreased in the test group receiving 200mg/kg bw compared with the control group. However, it has no effect on other blood parameters (P<0.05). The Baneh extract increased the number of RBCs and Hb concentration that can be due to the increase in the hematopoiesis process. Moreover, increased WBC after treatment with Baneh extract can enhance the body resistance against pathogenic agents. | ||
| کلیدواژهها [English] | ||
| Baneh (Pistacia atlantica Desf.), traditional medicine, oral administration, hematological tests | ||
| مراجع | ||
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