News

a.z
Sadeghian, A., Rakhshandeh, H., Sadeghian, M., Sadeghian, H. (2006). Effect of Methanol Extract of Plumbago on Candida albicans. , 22(1), 60-64. doi: 10.22092/ijmapr.2006.115001
A. Sadeghian; H. Rakhshandeh; M. Sadeghian; H. Sadeghian. "Effect of Methanol Extract of Plumbago on Candida albicans". , 22, 1, 2006, 60-64. doi: 10.22092/ijmapr.2006.115001
Sadeghian, A., Rakhshandeh, H., Sadeghian, M., Sadeghian, H. (2006). 'Effect of Methanol Extract of Plumbago on Candida albicans', , 22(1), pp. 60-64. doi: 10.22092/ijmapr.2006.115001
Sadeghian, A., Rakhshandeh, H., Sadeghian, M., Sadeghian, H. Effect of Methanol Extract of Plumbago on Candida albicans. , 2006; 22(1): 60-64. doi: 10.22092/ijmapr.2006.115001

Effect of Methanol Extract of Plumbago on Candida albicans

تحقیقات گیاهان دارویی و معطر ایران
Article 10, Volume 22, Issue 1 - Serial Number 31, April 2006, Pages 60-64    PDF (706.97 K)
Document Type: Research Paper
DOI: 10.22092/ijmapr.2006.115001
Authors
A. Sadeghian* 1; H. Rakhshandeh2; M. Sadeghian3; H. Sadeghian4
1Microbiology group, Mashhad University of Medical Science
2Pharmaclogy group, Mashhad University of Medical Science
3Student of Mashhad University of Medical Science
4PhD student of chemistry, Mashhad University
Abstract
In folk medicine, Plumbago has beenused because of antifungal property for precaution in treating mite infections. As the extract's effects of different species of Plumbago has been studied, in this research the antifungal effects of root of the European species of Plumbago was studied. For this reason methanol extract was prepared by soxhelet method and different concentrations of the extract were applied on standard and nosocomial Candida albicans and other fungus, by agar dilution and cylinder plate methods. Fungus were taken from blood, feces, spinal fluid, wound, vagina and so on. Clotrimasol was used as positive control drug. The results showed that, among the extracts, methanol extract 2% had significant antifungal activity, and in the other plates with extracts of 1.5%, 1%, 0.5% and 0/25% there was 95%, 73%, 70% and 61% inhibition of growth, respectively. Effects of methanol extract in comparison with clotrimasol were as follow; 1mg/100ml of extract was equal to 10mg/ml clotrimasol, 1.5mg/100ml of extract was equal to 20mg/ml clotrimasol, 2mg/100ml of extract was equal to 30mg/ml clotrimasol and 3mg/100ml of extract was equal to 40mg/ml clotrimasol. 
Keywords
Candida albicans; Plumbago; antifungal
References

- زرگری، ع.، 1365. گیاهان داروئی، انتشارات امیر کبیر، تهران، 940 صفحه .  

- Emerson S. F., Sharada, A.C. and Uma Devi, P., 1993. Toxic effects of crude root extract of Plumbago rosea on mice and rats, Journal of Ethnopharmacoloy, 38(1): 79-84.

- Jawetz, E., Melnick, J.L. and Adelberg, E.A., 2001. Medical Microbiology. 20th. Edition, Lange Medical books / McGraw- Hill, pp 550-551.

- Joklik, W.K. and Willett, H.P., 2002.  Zinsser Microbiology.

- Lewis, RE., Klepser, ME., 1999. The changing face of the nosocomial candidemia:  Epidemiology, resistance, and drug therapy. American Journal Health system, 56: 3-6.

- Muller, F.M., Groll, A.H. and Walsh, J., 1999. Current approaches to diagnosis and treatment of fungal infections in children infected with HIV, Europian Journal Pedetritic, 158: 187-189.

- Murray, P.R. and Rosenthal, K.S., 2002. Medical Microbiology, Mosby, 4th Edition, USA, pp: 664-667.

- Pfaller, MA., 1996. Nosocomial candidiasis, Emergency species, reservoirs and modes of transmission. Clinical Infection Disease, 22: 89-91.

- Suresh R.J., Rajeswara R.P. and Reddy, MS., 2002. Effects of Heliotropium indicum, plumbago zeylanicum and acalypha indica in rats. Journal of Ethnopharmacology, 79(2): 249-251

- Strohl, W.A., Rouse, H. and fisher, B.D. 2001. Microbiology. First Edition, LIPPINCOTT WILLIAMS WILKINS, pp: 274-275. 

Statistics
Article View: 607
PDF Download: 432


counter
Journal management system. designed by sinaweb