Mohseni, F., Shohreh, B., Dirandeh, E., Ansari Pirsaraei, Z. (2017). Association between blood metabolites, tumor necrosis factor alpha concentrations and metabolic disorders in Holstein cows during transition period. , 30(3), 147-153. doi: 10.22092/vj.2017.109883
F. Mohseni; B. Shohreh; Essa Dirandeh; Z. Ansari Pirsaraei. "Association between blood metabolites, tumor necrosis factor alpha concentrations and metabolic disorders in Holstein cows during transition period". , 30, 3, 2017, 147-153. doi: 10.22092/vj.2017.109883
Mohseni, F., Shohreh, B., Dirandeh, E., Ansari Pirsaraei, Z. (2017). 'Association between blood metabolites, tumor necrosis factor alpha concentrations and metabolic disorders in Holstein cows during transition period', , 30(3), pp. 147-153. doi: 10.22092/vj.2017.109883
Mohseni, F., Shohreh, B., Dirandeh, E., Ansari Pirsaraei, Z. Association between blood metabolites, tumor necrosis factor alpha concentrations and metabolic disorders in Holstein cows during transition period. , 2017; 30(3): 147-153. doi: 10.22092/vj.2017.109883

Association between blood metabolites, tumor necrosis factor alpha concentrations and metabolic disorders in Holstein cows during transition period

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 17, Volume 30, Issue 3 - Serial Number 116, September 2017, Pages 147-153    PDF (811.58 K)
Document Type: Full Research Paper
DOI: 10.22092/vj.2017.109883
Authors
F. Mohseni; B. Shohreh; Essa Dirandeh* ; Z. Ansari Pirsaraei
Department of Animal Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.
Abstract
The objectives of present study was to evaluate the association among blood metabolites, tumor necrosis factor (TNF)-alpha and metabolic diseases in Holstein cows during transition period. Pregnant multiparous Holstein cows (N = 50), with body condition scores (BCS) 3.5±0.75 and third parity were selected. Blood samples were collected weekly from 2 week prior to calving to 2 weeks after calving to determine plasma concentrations of non-esterifies fatty acids (NEFA), beta-Hydroxyl butyrate acid (BHBA) and activity of aspartate aminotransferase (AST) and alanine aminotrans-ferase (ALT) enzymes. According to above parameters cows divided into healthy (N =10) and diseases cow (n= 10) and plasma concentrations of glucose, insulin and TNF-α compared weekly from 2 week prior to calving to 2 weeks after calving.Results showed cows with metabolic disorders had higher plasma concentrations of NEFA, BHBA, AST and TNF-alpha compared to healthy cows (P < 0.05) but conversely plasma concentrations of glucose and insulin were lower in cows with metabolic disorders compared to healthy cows (P < 0.05). Plasma glucose concentration affected by time and increased from -14 to calving in both treatments and after that decreased until d +14. Glucose concentrations at d +7 and +14 were greater in healthy cows compared to cows with metabolic disorders. Plasma TNF-α concentration were greater in cows with metabolic disorders compared to healthy cows during whole esxperiment. In conclusion due to greater TNF-α concentration in cows with metabolic disorders before calving, using this item could be useful to predict cows suspicious to metabolic disorders after calving therefore we can use suitable strategies to prevent or decreased incidence of metabolic disorders.
Keywords
Fatty liver; Glucose; Holstein cow; ketosis; Tumor necrosis factor alpha
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