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Esfandiari, A., Bazdar, H. (2016). An investigation on the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male Wistar rats.. , 29(3), 60-66. doi: 10.22034/vj.2016.106298
A. Esfandiari; H. Bazdar. "An investigation on the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male Wistar rats.". , 29, 3, 2016, 60-66. doi: 10.22034/vj.2016.106298
Esfandiari, A., Bazdar, H. (2016). 'An investigation on the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male Wistar rats.', , 29(3), pp. 60-66. doi: 10.22034/vj.2016.106298
Esfandiari, A., Bazdar, H. An investigation on the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male Wistar rats.. , 2016; 29(3): 60-66. doi: 10.22034/vj.2016.106298

An investigation on the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male Wistar rats.

تحقیقات دامپزشکی و فرآورده‌های بیولوژیک
Article 9, Volume 29, Issue 3 - Serial Number 112, September 2016, Pages 60-66    PDF (4.59 M)
Document Type: Full Research Paper
DOI: 10.22034/vj.2016.106298
Authors
A. Esfandiari* 1; H. Bazdar2
1Assistant Professor Department of Basic Sciences, Kazeroon Branch Islamic Azad University. Kazeroon, Iran.
2Kazeroon Branch Islamic Azad University. Kazeroon, Iran.
Abstract

The aim of this study was to investigate the effect of Naloxone on histomorphometrical change of testis induced by morphine administration in male wistar rats. Fifteen male wistar rats divided into three groups : 1- control group. 2- Morphine experimental group (IP received 5 mg/kg morphine for 30 days). 3- Morphine-naloxone experimental group (IP received 5 mg/kg morphine for 30 days and one dose IP received 2mg/kg Naloxone at 30th day). Ten days after the end of experiment the specimens were obtained at 40th . Results showed that the thickness of the wall of seminiferous tubule, and the weight of testis, in morphine experimental group significantly decreased (p ≤ 0.05). Also, the number of the spermatogenic cells in the seminiferous tubule were decreased in morphine experimental group. In addition, the thickness of the wall of seminiferous tubule, the weight of testis and the number of the spermatogenic cells were increased in morphine-naloxone experimental group compared with morphine experimental group but the number of the spermatogenic cells increased in morphine-naloxone experimental group with no significant difference in comparison with morphine experimental group (0.05 ≤ P). It is concluded that morphine decreased the sexual activity, the number of spermatogenic cells, the thickness of seminiferous tubule, and the weight of testis but Naloxone can improve this decrement.
Keywords
Naloxone; histomorphometric; Morphine; rat
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